Polymorphonuclear neutrophils are the first cells recruited to inflammatory sites and form the
earliest line of defense against invading microorganisms. Neutrophil elastase, proteinase 3 …

The periodontal diseases are highly prevalent and can affect up to 90% of the worldwide
population. Gingivitis, the mildest form of periodontal disease, is caused by the bacterial …

Lung metastasis is the major cause of breast cancer-related mortality. The neutrophil-
associated inflammatory microenvironment aids tumor cells in metastatic colonization in …

Virtually all of the measurable cell-mediated cytotoxicity delivered by cytotoxic T
lymphocytes and natural killer cells comes from either the granule exocytosis pathway or the …

The scientific literature during the last ten years has seen an exponential increase in the
number of reports claiming links for genetic polymorphisms with a variety of medical …

Antimicrobial peptides (AMPs) are a wide-ranging class of host-defense molecules that act
early to contest against microbial invasion and challenge. These are small cationic peptides …

Cathepsin C (CatC) is a cysteine dipeptidyl aminopeptidase that activates most of tissue-
degrading elastase-related serine proteases. Thus, CatC appears as a potential therapeutic …

Gorr S‐U, Abdolhosseini M. Antimicrobial peptides and periodontal disease. J Clin
Periodontol 2011; 38 (Suppl. 11): 126–141. doi: 10.1111/j. 1600‐051X. 2010.01664. x …

Dipeptidyl peptidase I (DPPI) or cathepsin C is the physiological activator of groups of serine
proteases from immune and inflammatory cells vital for defense of an organism. The …

Cathepsin C (CatC) is a highly conserved tetrameric lysosomal cysteine dipeptidyl
aminopeptidase. The best characterized physiological function of CatC is the activation of …