Atherosclerotic cardiovascular (CV) disease (ASCVD) incidence and mortality rates are
declining in many countries in Europe, but it is still a major cause of morbidity and mortality …

Type 2 Diabetes Mellitus (T2DM), one of the most common metabolic disorders, is caused
by a combination of two primary factors: defective insulin secretion by pancreatic β-cells and …

Recent advances in human genetics, together with a large body of epidemiologic,
preclinical, and clinical trial results, provide strong support for a causal association between …

OP-EHEA191011_online 2313..2340 Page 1 Low-density lipoproteins cause atherosclerotic
cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus …

Background Genetic, observational, and clinical intervention studies indicate that circulating
levels of triglycerides and cholesterol transported in triglyceride-rich lipoproteins (remnant …

The American College of Cardiology (ACC) has a long history of developing documents (eg,
decision pathways, health policy statements, appropriate use criteria) to provide members …

version of the Guidelines, which is freely available via the ESC and EAS websites and
hosted on their journals' websites (EHJ and Atherosclerosis Journal). The National Cardiac …

Introduction Dyslipidemia may be defined as increased levels of serum total cholesterol
(TC), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), or a decreased serum …

Previous interest in high-density lipoproteins (HDLs) focused on their possible protective
role in atherosclerotic cardiovascular disease (ASCVD). Evidence from genetic studies and …

Aims The expression of GADD153 (growth arrest and DNA damage-inducible gene 153), an
apoptosis-regulated gene, increases during endoplasmic reticulum (ER) stress. How …