Fungal infections cause severe and life-threatening complications especially in
immunocompromised individuals. Antifungals targeting cellular machinery and cell …

The present review summarizes recent publications devoted to aminoglycosides that study
the main types of resistance to antibiotics of this class and the main directions of chemical …

The conjugation of hydrophobic group (s) to the polycationic hydrophilic core of the antibiotic
drugs aminoglycosides (AGs), targeting ribosomal RNA, has led to the development of …

Background: Gentamicin is a broad-spectrum aminoglycoside antibiotic produced by
Micromonospora purpurea bacteria, effective against Gram-negative bacterial infections …

Gap-junction channels formed by two connexin hemichannels play diverse and pivotal roles
in intercellular communication and regulation. Normally hemichannels at the plasma …

Aminoglycosides are one of the first classes of antibiotics to have been used clinically, and
they are still being used today. They have a broad spectrum of antimicrobial activity, making …

Development of novel therapeutics to treat antibiotic-resistant infections, especially those
caused by ESKAPE pathogens, is urgent. One of the most critical pathogens is P …

Аннотация В обзоре обобщены публикации последних лет, посвященные
аминогликозидам, изучению основных типов устойчивости к антибиотикам данного …

Abstract The synthesis of 3-and 6-aminosugars from the old route requires many synthetic
steps and is challenging. An alternative approach is to utilize acid-catalyzed hydrolysis of …