Blood–brain barrier (BBB) is a natural protective membrane that prevents central nervous
system (CNS) from toxins and pathogens in blood. However, the presence of BBB …

Recent advancements in gene supplementation therapy are expanding the options for the
treatment of neurological disorders. Among the available delivery vehicles, adeno …

Adeno-associated virus (AAV) has emerged as a pivotal delivery tool in clinical gene
therapy owing to its minimal pathogenicity and ability to establish long-term gene expression …

A healthy brain is protected by the blood–brain barrier (BBB), which is formed by the
endothelial cells that line brain capillaries. The BBB plays an extremely important role in …

There are numerous mechanisms by which glioblastoma cells evade immunological
detection, underscoring the need for strategic combinatorial treatments to achieve …

Aberrant inorganic phosphate (Pi) homeostasis causes brain calcification and aggravates
neurodegeneration, but the underlying mechanism remains unclear. Here, we found that …

Drug delivery to the brain is crucial in the treatment for central nervous system disorders.
While significant progress has been made in recent years, there are still major challenges in …

Alzheimer's disease (AD) is the most burdensome aging‐associated neurodegenerative
disorder, and its treatment encounters numerous failures during drug development …

Spinal cord injury is a serious traumatic disease. As Ferroptosis has been increasingly
studied in recent years, it has been found to be closely related to the pathophysiological …

Recombinant adeno-associated viruses (rAAVs) have emerged as an attractive tool for gene
delivery, and demonstrated tremendous promise in gene therapy and gene editing …