This review analyses the literature concerning non-fluorescent and fluorescent probes for
nucleic acid imaging in fixed and living cells from the point of view of their suitability for …

Nucleic acids are the molecular targets of many clinical anticancer drugs. However,
compared with proteins, nucleic acids have traditionally attracted much less attention as …

Despite the growing importance of fluorinated organic compounds in drug development,
there are no direct protocols for the fluorination of aliphatic CH bonds using conveniently …

Pyrrole-imidazole polyamides are a class of small molecules that can be programmed to
bind a broad repertoire of DNA sequences, disrupt transcription factor− DNA interfaces, and …

Friedreich ataxia (FRDA), the most common inherited ataxia, is caused by transcriptional
silencing of the nuclear FXN gene, encoding the essential mitochondrial protein frataxin …

Abstract Pyrrole–imidazole polyamides (Py–Im polyamides) are cell-permeable compounds
that bind to the minor groove of double-stranded DNA in a sequence-specific manner …

Pyrrole–imidazole (PI) polyamides are small synthetic molecules that recognize and attach
to the minor groove of DNA, thereby inhibiting gene transcription by blocking transcription …

Recent innovations in cutting-edge sequencing platforms have allowed the rapid
identification of genes associated with communicable, noncommunicable and rare diseases …

A survey of literature covering the synthesis of xanthene dyes and their applications during
the period 2000-2016 is carried out. A comparison of various synthetic strategies in terms of …

Hairpin pyrrole− imidazole (Py-Im) polyamides are a class of cell-permeable DNA-binding
small molecules that can disrupt transcription factor− DNA binding and regulate …