Proopiomelanocortin (POMC) is a key mediator of satiety. Epigenetic marks such as DNA
methylation may modulate POMC expression and provide a biological link between early life …

Aim and objective To present the evidence in relation to early life nutrition and foetal
programming for adult disease. Background Epigenetics is a new and growing area of study …

Maternal prepregnancy obesity is associated with impaired cardiometabolic health in
offspring. Whether these associations reflect direct intrauterine causal mechanisms remains …

Aims/hypothesis Maternal obesity is associated with an increased risk of obesity and
impaired glucose homeostasis in offspring. However, it is not known whether a gestational …

Maternal nutrition may influence metabolic profiles in offspring. We aimed to investigate the
effect of maternal folic acid supplement on glucose metabolism in mouse offspring fed a high …

Background A high proportion of women start pregnancy overweight or obese. According to
the developmental overnutrition hypothesis, this could lead offspring to have metabolic …

Metabolic syndrome (MetS) is a worldwide public health issue characterized by a set of risk
factors for cardiovascular disease. MetS can originate in early life by developmental …

Solid epidemiological evidence indicates that part of the risk of obesity in adulthood could
be programmed during prenatal development by the quality of maternal nutrition …

In utero exposure to the ubiquitous plasticizer, bisphenol A (BPA) is associated with
offspring obesity. As food intake/appetite is one of the critical elements contributing to …

Although brown adipose tissue (BAT) is one of the smallest organs in the body, it has the
potential to have a substantial impact on both heat production as well as fat and …