Drug resistance in tuberculosis (TB) is a particular problem because the lengthy therapy of
at least 6 months makes patient compliance very difficult, which frequently creates drug …

Tuberculosis (TB) is a formidable infectious disease that remains a major cause of death
worldwide today. Escalating application of genomic techniques has expedited the …

Ethambutol (EMB) is an antimycobacterial drug used extensively for the treatment of
tuberculosis caused by Mycobacterium tuberculosis. EMB targets the biosynthesis of the cell …

Drug-resistant tuberculosis (TB) poses a significant challenge to the successful treatment
and control of TB worldwide. Resistance to anti-TB drugs has existed since the beginning of …

Whole-genome sequencing (WGS) is now common as a result of new technologies that can
rapidly sequence a complete bacterial genome for US $500 or less. Many studies have …

Modification of codon 306 in embB is regarded as the main mechanism leading to
ethambutol (ETB) resistance in clinical isolates of Mycobacterium tuberculosis. However …

Tuberculosis (TB) is caused by infection with Mycobacterium tuberculosis, which is
transmitted through inhalation of aerosolized droplets. TB mainly attacks the lungs, but can …

To better understand the molecular mechanisms of Ethambutol (EMB) resistance, the mutant
hot spot region of five genes (embB, embA, embC, embR, and ubiA) was amplified and …

Tuberculosis is a fatal disease caused by Mycobacterium tuberculosis with highest morbidity
and mortality every year. The evolution of anti-TB drugs is promising in controlling and …

Objectives To determine the association between embB mutations and drug resistance, and
to further investigate the mechanism of embB mutations involved in the development of …