Autophagy is a core molecular pathway for the preservation of cellular and organismal
homeostasis. Pharmacological and genetic interventions impairing autophagy responses …

Autosomal dominant polycystic kidney disease (ADPKD) is one of the most common,
potentially lethal, monogenic diseases and is caused predominantly by mutations in …

Nutrients such as glucose, amino acids and lipids are fundamental sources for the
maintenance of essential cellular processes and homeostasis in all organisms. The nutrient …

Autophagy is a highly conserved process that degrades cellular long-lived proteins and
organelles. Accumulating evidence indicates that autophagy plays a critical role in kidney …

Autophagy is a highly regulated lysosomal protein degradation pathway that removes
protein aggregates and damaged or excess organelles to maintain intracellular homeostasis …

Autophagy is a cellular homeostatic program for the turnover of cellular organelles and
proteins, in which double-membraned vesicles (autophagosomes) sequester cytoplasmic …

Activation of mTORC1 (mechanistic target of rapamycin complex 1) in renal tissue has been
reported in chronic kidney disease (CKD)-induced renal fibrosis. However, the molecular …

Apoptosis in the cystic epithelium is observed in most rodent models of polycystic kidney
disease (PKD) and in human autosomal dominant PKD (ADPKD). Apoptosis inhibition …

A number of syndromic disorders have renal cysts as a component of their phenotypes.
These disorders can generally be distinguished from autosomal dominant polycystic kidney …

Activation of the mammalian target of rapamycin (mTOR) signaling pathway is aberrant in
autosomal-dominant polycystic kidney disease (ADPKD). The mTOR inhibitors, such as …