Snake venoms in drug discovery: Valuable therapeutic tools for life saving
Animal venoms are used as defense mechanisms or to immobilize and digest prey. In fact,
venoms are complex mixtures of enzymatic and non-enzymatic components with specific …
venoms are complex mixtures of enzymatic and non-enzymatic components with specific …
Haemostatically active proteins in snake venoms
T Sajevic, A Leonardi, I Križaj - Toxicon, 2011 - Elsevier
Snake venom proteins that affect the haemostatic system can cause (a) lowering of blood
coagulability,(b) damage to blood vessels, resulting in bleeding,(c) secondary effects of …
coagulability,(b) damage to blood vessels, resulting in bleeding,(c) secondary effects of …
Polymorphic toxin systems: comprehensive characterization of trafficking modes, processing, mechanisms of action, immunity and ecology using comparative …
Background Proteinaceous toxins are observed across all levels of inter-organismal and
intra-genomic conflicts. These include recently discovered prokaryotic polymorphic toxin …
intra-genomic conflicts. These include recently discovered prokaryotic polymorphic toxin …
[HTML][HTML] Beyond the 'big four': Venom profiling of the medically important yet neglected Indian snakes reveals disturbing antivenom deficiencies
RRS Laxme, S Khochare, HF de Souza… - PLoS neglected …, 2019 - journals.plos.org
Background Snakebite in India causes the highest annual rates of death (46,000) and
disability (140,000) than any other country. Antivenom is the mainstay treatment of …
disability (140,000) than any other country. Antivenom is the mainstay treatment of …
Comprehensive analysis of the HEPN superfamily: identification of novel roles in intra-genomic conflicts, defense, pathogenesis and RNA processing
Background The major role of enzymatic toxins that target nucleic acids in biological
conflicts at all levels has become increasingly apparent thanks in large part to the advances …
conflicts at all levels has become increasingly apparent thanks in large part to the advances …
Phylovenomics of Daboia russelii across the Indian subcontinent. Bioactivities and comparative in vivo neutralization and in vitro third-generation antivenomics of …
Russell's viper (Daboia russelii) is, together with Naja naja, Bungarus caeruleus and Echis
carinatus, a member of the medically important 'Big Four'species responsible for causing a …
carinatus, a member of the medically important 'Big Four'species responsible for causing a …
Evolution of the deaminase fold and multiple origins of eukaryotic editing and mutagenic nucleic acid deaminases from bacterial toxin systems
The deaminase-like fold includes, in addition to nucleic acid/nucleotide deaminases, several
catalytic domains such as the JAB domain, and others involved in nucleotide and ADP …
catalytic domains such as the JAB domain, and others involved in nucleotide and ADP …
A novel immunity system for bacterial nucleic acid degrading toxins and its recruitment in various eukaryotic and DNA viral systems
The use of nucleases as toxins for defense, offense or addiction of selfish elements is widely
encountered across all life forms. Using sensitive sequence profile analysis methods, we …
encountered across all life forms. Using sensitive sequence profile analysis methods, we …
A brief review of the scientific history of several lesser-known snake venom proteins: L-amino acid oxidases, hyaluronidases and phosphodiesterases
JW Fox - Toxicon, 2013 - Elsevier
When considering the proteins and toxins in snake venom one's thoughts generally migrate
to the proteinases, neurotoxins and phospholipases since these families of proteins are …
to the proteinases, neurotoxins and phospholipases since these families of proteins are …
Venom proteomics and antivenom neutralization for the Chinese eastern Russell's viper, Daboia siamensis from Guangxi and Taiwan
The eastern Russell's viper (Daboia siamensis) causes primarily hemotoxic envenomation.
Applying shotgun proteomic approach, the present study unveiled the protein complexity …
Applying shotgun proteomic approach, the present study unveiled the protein complexity …