Neuroprotective effects of thiamine and precursors with higher bioavailability: focus on benfotiamine and dibenzoylthiamine

M Sambon, P Wins, L Bettendorff - International journal of molecular …, 2021 - mdpi.com
Thiamine (vitamin B1) is essential for brain function because of the coenzyme role of
thiamine diphosphate (ThDP) in glucose and energy metabolism. In order to compensate …

Antioxidants in potatoes: A functional view on one of the major food crops worldwide

H Hellmann, A Goyer, DA Navarre - Molecules, 2021 - mdpi.com
With a growing world population, accelerating climate changes, and limited arable land, it is
critical to focus on plant-based resources for sustainable food production. In addition, plants …

Benfotiamine and cognitive decline in Alzheimer's disease: results of a randomized placebo-controlled phase IIa clinical trial

GE Gibson, JA Luchsinger, R Cirio… - Journal of …, 2020 - content.iospress.com
Background: In preclinical models, benfotiamine efficiently ameliorates the clinical and
biological pathologies that define Alzheimer's disease (AD) including impaired cognition …

Synthetic Thioesters of Thiamine: Promising Tools for Slowing Progression of Neurodegenerative Diseases

L Bettendorff - International Journal of Molecular Sciences, 2023 - mdpi.com
Thiamine (vitamin B1) is essential for the brain. This is attributed to the coenzyme role of
thiamine diphosphate (ThDP) in glucose and energy metabolism. The synthetic thiamine …

Thiamine demonstrates bio-preservative and anti-microbial effects in minced beef meat storage and lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages

AB Hsouna, A Boye, BB Ackacha, W Dhifi, RB Saad… - Animals, 2022 - mdpi.com
Simple Summary Thiamine (TA), also known as vitamin B1, is an essential amino acid
derived from food sources for normal body function. TA is thought to have antioxidant …

Neuroblastoma is associated with alterations in gut microbiome composition subsequent to maternal microbial seeding

M Valles-Colomer, P Manghi, F Cumbo, G Masetti… - …, 2024 - thelancet.com
Background Neuroblastoma is the most frequent extracranial solid tumour in children,
accounting for∼ 15% of deaths due to cancer in childhood. The most common clinical …

Thiamine and benfotiamine: Focus on their therapeutic potential

I Bozic, I Lavrnja - Heliyon, 2023 - cell.com
Thiamine, also known as vitamin B1, is an essential nutrient that plays a crucial role in
energy metabolism and overall health. It is a water-soluble vitamin that plays an important …

Dibenzoylthiamine has powerful antioxidant and anti-inflammatory properties in cultured cells and in mouse models of stress and neurodegeneration

M Sambon, A Gorlova, A Demelenne, J Alhama-Riba… - Biomedicines, 2020 - mdpi.com
Thiamine precursors, the most studied being benfotiamine (BFT), have protective effects in
mouse models of neurodegenerative diseases. BFT decreased oxidative stress and …

Emerging Alzheimer's disease therapeutics: promising insights from lipid metabolism and microglia-focused interventions

NS Tobeh, KD Bruce - Frontiers in Aging Neuroscience, 2023 - frontiersin.org
More than 55 million people suffer from dementia, with this number projected to double
every 20 years. In the United States, 1 in 3 aged individuals dies from Alzheimer's disease …

Role of the synthetic B1 vitamin sulbutiamine on health

B Starling-Soares, P Carrera-Bastos… - Journal of nutrition …, 2020 - Wiley Online Library
Sulbutiamine is a thiamine derivative developed in Japan in the mid‐60's as a beriberi
treatment drug. Since then, different potential applications have been described. For …