CaMKII (the multifunctional Ca2+ and calmodulin-dependent protein kinase II) is a highly
validated signal for promoting a variety of common diseases, particularly in the …

The prevalence of diabetes is rapidly increasing and closely associated with cardiovascular
morbidity and mortality. While the major cardiovascular complication associated with …

Rationale: Diabetes mellitus is a complex, multisystem disease, affecting large populations
worldwide. Chronic CaMKII (Ca2+/calmodulin-dependent kinase II) activation may occur in …

Junctophilins (JPHs) comprise a family of structural proteins that connect the plasma
membrane to intracellular organelles such as the endo/sarcoplasmic reticulum (ER/SR) …

Aberrant expression of the cardiac gap junction protein connexin-43 (Cx43) has been
suggested as playing a role in the development of cardiac disease in the mdx mouse model …

Diastolic dysfunction (DD) underlies heart failure with preserved ejection fraction (HFpEF), a
clinical syndrome associated with aging that is becoming more prevalent. Despite extensive …

Background Insulin resistance (IR) is considered as a risk factor for atrial fibrillation (AF)
even before diabetes develops. The pathophysiology and underlying mechanism are largely …

Diabetes mellitus (DM) is associated with increased arrhythmia. Type 2 DM (T2DM) mice
showed prolonged QT interval and increased ventricular arrhythmic inducibility …

Duchenne muscular dystrophy (DMD) cardiomyopathy (DCM) is characterized by a
hypokinetic, dilated phenotype progressively increasing with age. Regular cardiac care is …

Calcium/calmodulin-dependent protein kinase II δ (CaMKIIδ) has a pivotal role in cardiac
signaling. Constitutive and deleterious CaMKII" autonomous" activation is induced by …