Trypanosoma brucei spp. cause African human and animal trypanosomiasis, a burden on
health and economy in Africa. These hemoflagellates are distinguished by a kinetoplast …

Kinetoplastids are flagellated protozoans, whose members include the pathogens
Trypanosoma brucei, T. cruzi and Leishmania species, that are considered among the …

Survival of bloodstream form Trypanosoma brucei, the agent of African sleeping sickness,
normally requires mitochondrial gene expression, despite the absence of oxidative …

The basic mechanism of uridine insertion/deletion RNA editing in mitochondria of
kinetoplastid protists has been established for some time but the molecular details remained …

The Cys2His2 zinc finger is one of the most common DNA-binding motifs in Eukaryota. A
simple mode of DNA recognition by the Cys2His2 zinc finger domain provides an ideal …

African trypanosomes, early diverged eukaryotes and the agents of sleeping sickness, have
several basic cellular processes that are remarkably divergent from those in their …

A multiprotein, high molecular weight complex active in both U‐insertion and U‐deletion as
judged by a pre‐cleaved RNA editing assay was isolated from mitochondrial extracts of …

A 3′ terminal RNA uridylyltransferase was purified from mitochondria of Leishmania
tarentolae and the gene cloned and expressed from this species and from Trypanosoma …

The editosome is a multiprotein complex that catalyzes the insertion and deletion of
uridylates that occurs during RNA editing in trypanosomatids. We report the identification of …

A number of mitochondrial proteins have been identified in Leishmania sp. and
Trypanosoma brucei that may be involved in U-insertion/deletion RNA editing. Only a few of …