Inhibition of p90 ribosomal S6 kinases disrupts melanoma cell growth and immune evasion
C Kosnopfel, S Wendlinger, H Niessner… - Journal of Experimental …, 2023 - Springer
Background The mitogen-activated protein kinase (MAPK) signaling pathway is frequently
hyperactivated in malignant melanoma and its inhibition has proved to be an efficient …
hyperactivated in malignant melanoma and its inhibition has proved to be an efficient …
An oral first‐in‐class small molecule RSK inhibitor suppresses AR variants and tumor growth in prostate cancer
M Ushijima, M Shiota, T Matsumoto… - Cancer …, 2022 - Wiley Online Library
Ribosomal S6 kinase has been shown to play a key role in cellular resistance to endocrine
therapy in prostate cancer through its regulation of YB‐1/androgen receptor (AR) signaling …
therapy in prostate cancer through its regulation of YB‐1/androgen receptor (AR) signaling …
Synthesis and anti‐tumor activity evaluation of 1H‐pyrrolo [2, 3‐b] pyridine‐2‐carboxamide derivatives with phenyl sulfonamide groups as potent RSK2 inhibitors
X Zhang, G Zheng, S Gao, F Zhou, T Pan… - Chemical Biology & …, 2024 - Wiley Online Library
Abstract Ribosome S6 Protein Kinase 2 (RSK2) is involved in many signal pathways such as
cell growth, proliferation, survival and migration in tumors. Also, RSK2 can phosphorylate YB …
cell growth, proliferation, survival and migration in tumors. Also, RSK2 can phosphorylate YB …