Comparative genomics shows that a substantial fraction of the genes in sequenced
genomes encodes 'conserved hypothetical'proteins, ie those that are found in organisms …

Construction of a chemical system capable of replication and evolution, fed only by small
molecule nutrients, is now conceivable. This could be achieved by stepwise integration of …

Based on the genomic sequence data of Escherichia coli K-12 strain, we have constructed a
complete set of cloned individual genes encoding Histidine-tagged proteins with or without …

RNA metabolism, broadly defined as the compendium of all processes that involve RNA,
including transcription, processing and modification of transcripts, translation, RNA …

While N6‐methyladenosine (m6A) is a well‐known epigenetic modification in bacterial DNA,
it remained largely unstudied in eukaryotes. Recent studies have brought to fore its potential …

AdoMet-dependent methylation of histones is part of the" histone code" that can profoundly
influence gene expression. We describe the crystal structure of Neurospora DIM-5, a histone …

MT-A70 is the S-adenosylmethionine-binding subunit of human mRNA: m6A methyl-
transferase (MTase), an enzyme that sequence-specifically methylates adenines in pre …

Many proteins are modified by posttranslational methylation, introduced by a number of
methyltransferases (MTases). Protein methylation plays important roles in modulating …

We have analyzed existing methodologies and created novel methodologies for the
automatic assignment of S-adenosylmethionine (AdoMet)-dependent methyltransferase …

Modified nucleotides in non-coding RNAs, such as tRNAs and snRNAs, represent an
important layer of gene expression regulation through their ability to fine-tune mRNA …