Tissue injury initiates a complex repair process, which in some organisms can lead to the
complete regeneration of a tissue. In mammals, however, the repair of most organs is …

Zebrafish are teleosts (bony fish) that share with mammals a common ancestor belonging to
the phylum Osteichthyes, from which their endoskeletal systems have been inherited …

Tissue damage can resolve completely through healing and regeneration, or can produce
permanent scarring and loss of function. The response to tissue damage varies across …

Neutrophils and macrophages, as key mediators of inflammation, have defined functionally
important roles in mammalian tissue repair. Although recent evidence suggests that similar …

The zebrafish fin provides a valuable model to study the epimorphic type of regeneration,
whereby the amputated part of the appendage is nearly perfectly replaced. To accomplish …

Recent advances in limb regeneration are revealing the molecular events that integrate
growth control, cell fate programming, and positional information to yield the exquisite …

The inhibitory extracellular matrix in a spinal lesion site is a major impediment to axonal
regeneration in mammals. In contrast, the extracellular matrix in zebrafish allows substantial …

For successful regeneration, the identity of the missing tissue must be specified according to
the pre-existing tissue. Planarians are ideal for the study of the mechanisms underlying this …

Zebrafish have the remarkable ability to fully regenerate a lost appendage, faithfully
restoring its size, shape and tissue patterning. Studies over the past decades have identified …

The ability to repair damaged or lost tissues varies significantly among vertebrates. The
regenerative ability of the heart is clinically very relevant, because adult teleost fish and …