Neutrophils have long been considered as cells playing a crucial role in the immune
defence against invading pathogens. Accumulating evidence strongly supported the direct …

Brucella abortus live vaccines have been used successfully to control bovine brucellosis
worldwide for decades. However, due to some limitations of these live vaccines, efforts are …

The protozoan Leishmania mexicana parasite causes chronic non-healing cutaneous
lesions in humans and mice with poor parasite control. The mechanisms preventing the …

Evasion of host immune responses is a prerequisite for chronic bacterial diseases; however,
the underlying mechanisms are not fully understood. Here, we show that the persistent …

Abstract Interleukin-10 (IL-10) is recognized as an anti-inflammatory cytokine that
downmodulates inflammatory immune responses at multiple levels. In innate cells …

Brucellosis is a bacterial disease of domestic animals and humans. The pathogenic ability of
Brucella organisms relies on their stealthy strategy and their capacity to replicate within host …

Neutrophils play a key role in the innate immune system's response to infection. They
eliminate microbes through phagocytosis, the production of ROS, and the secretion of …

Polymorphonuclear neutrophils (PMN) play a central role in inflammation and participate in
its control, notably by modulating dendritic cell (DC) functions via soluble mediators or cell …

Brucella abortus is a stealthy intracellular bacterial pathogen of animals and humans. This
bacterium promotes the premature cell death of neutrophils (PMN) and resists the killing …

Most bacterial infections induce the activation of polymorphonuclear neutrophils (PMNs),
enhance their microbicidal function, and promote the survival of these leukocytes for …