Antibiotic-resistant Mycobacterium tuberculosis strains are threatening progress in
containing the global tuberculosis epidemic. Mycobacterium tuberculosis is intrinsically …

For tuberculosis to be eradicated, the transmission of Multi-Drug-Resistant and eXtensively
Drug Resistant strains of Mycobacterium tuberculosis (MDR and XDR-TB) must be …

Page 1 Catalogue of mutations in Mycobacterium tuberculosis complex and their
association with drug resistance Second edition Page 2 Page 3 Catalogue of mutations in …

Background Global roll-out of rapid molecular assays is revolutionising the diagnosis of
rifampicin resistance, predictive of multidrug-resistance, in tuberculosis. However, 30% of …

Objectives Antimicrobial resistance (AMR) is a priority for surveillance in bacterial infections.
For leprosy, AMR has not been assessed because Mycobacterium leprae does not grow in …

Rifamycins are a class of antibiotics that were first discovered in 1957 and are known for
their use in treating tuberculosis (TB). Rifamycins exhibit bactericidal activity against many …

Tuberculosis (TB) caused by Mycobacterium tuberculosis (MTB) is the deadliest infectious
disease and the associated global threat has worsened with the emergence of drug …

Objective To investigate the mutations within the whole rpoB gene of Mycobacterium
tuberculosis and analyze their effects on rifampin (RIF) resistance based on crystal structure …

Low-level rifampin resistance associated with specific rpoB mutations (referred as
“disputed”) in Mycobacterium tuberculosis is easily missed by some phenotypic methods. To …

Tuberculosis (TB) is an infectious disease that poses a serious threat to human health.
Rifampin (RIF) is an important first-line anti-TB drug, and rifampin resistance (RIF-R) is a key …