Numerous studies have demonstrated that endothelial cells are capable of undergoing
endothelial to mesenchymal transition (EndMT), a newly recognized type of cellular …

Long-chain fatty acids are molecules that act as metabolic intermediates and constituents of
membranes; however, their novel role as signaling molecules in immune function has also …

Inflammatory diseases present a serious health challenge due to their widespread
prevalence and the severe impact on patients' lives. In the quest to alleviate the burden of …

Nitro-fatty acids (NO2-FAs) are unsaturated fatty acid nitration products that exhibit anti-
inflammatory actions in experimental mouse models of autoimmune and allergic diseases …

Recent studies in animal systems have shown that NO can interact with fatty acids to
generate nitro-fatty acids (NO 2-FAs). They are the product of the reaction between reactive …

To determine whether aorta becomes immune organ in pathologies, we performed
transcriptomic analyses of six types of secretomic genes (SGs) in aorta and vascular cells …

Endothelial-to-mesenchymal transition (EndMT) of glomerular vascular endothelial cells
(GEnCs) is now considered to play a critical role in diabetic nephropathy (DN). NOD2 is …

Sterile inflammation characterized by unresolved chronic inflammation is well established to
promote the progression of multiple autoimmune diseases, metabolic disorders …

Tissue fibrosis occurs in response to dysregulated metabolism, pro-inflammatory signaling
and tissue repair reactions. For example, lungs exposed to environmental toxins, cancer …

Sickle cell disease (SCD) is a hereditary hematological disease with high morbidity and
mortality rates worldwide. Despite being monogenic, SCD patients display a plethora of …