" Omics" in pharmaceutical research: overview, applications, challenges, and future perspectives.

SK Yan, RH Liu, HZ Jin, XR Liu, J Ye… - Chinese journal of …, 2015 - europepmc.org
In the post-genomic era, biological studies are characterized by the rapid development and
wide application of a series of" omics" technologies, including genomics, proteomics …

Application of pharmacogenomics to vaccines

GA Poland, IG Ovsyannikova, RM Jacobson - Pharmacogenomics, 2009 - Taylor & Francis
The field of pharmacogenomics and pharmacogenetics provides a promising science base
for vaccine research and development. A broad range of phenotype/genotype data …

[图书][B] Batch effects and noise in microarray experiments: sources and solutions

A Scherer - 2009 - Wiley Online Library
High-content, high-density long or short oligonucleotide microarrays for simultaneous
measurement of redundancy of RNA species are nowadays widely used for hypothesis …

Gene expression profiling reveals potential prognostic biomarkers associated with the progression of heart failure

A Maciejak, M Kiliszek, M Michalak, D Tulacz… - Genome medicine, 2015 - Springer
Background Heart failure (HF) is the most common cause of morbidity and mortality in
developed countries. Here, we identify biologically relevant transcripts that are significantly …

Update on myocarditis–what we know so far and where we may be heading

A Rroku, J Kottwitz, B Heidecker - European Heart Journal Acute …, 2021 - academic.oup.com
Myocarditis is defined as an inflammatory infiltration of the myocardium with associated
necrosis and/or degeneration, frequently resulting from different infectious or non-infectious …

Big data: the next frontier for innovation in therapeutics and healthcare

NT Issa, SW Byers… - Expert review of clinical …, 2014 - Taylor & Francis
Advancements in genomics and personalized medicine not only effect healthcare delivery
from patient and provider standpoints, but also reshape biomedical discovery. We are in the …

Transcriptomic biomarkers for the accurate diagnosis of myocarditis

B Heidecker, MM Kittleson, EK Kasper, IS Wittstein… - Circulation, 2011 - Am Heart Assoc
Background—Lymphocytic myocarditis is a clinically important condition that is difficult to
diagnose and distinguish. We hypothesized that the transcriptome obtained from an …

Differential expression of oxidative stress and inflammation related genes in peripheral blood mononuclear cells in response to a low-calorie diet: a nutrigenomics …

AB Crujeiras, D Parra, FI Milagro… - OMICS A Journal of …, 2008 - liebertpub.com
Nutrigenomics is a new application of omics technologies in nutritional science.
Nutrigenomics aims to identify molecular markers of diet-related diseases and mechanisms …

The gene expression profile of patients with new-onset heart failure reveals important gender-specific differences

B Heidecker, G Lamirault, EK Kasper… - European heart …, 2010 - academic.oup.com
Aims We sought to test the hypothesis that inherent biological factors contribute to gender
differences in disease pathophysiology of new-onset heart failure (HF), which can be …

Integration of epigenetic mechanisms into non-genotoxic carcinogenicity hazard assessment: Focus on DNA methylation and histone modifications

D Desaulniers, P Vasseur, A Jacobs… - International Journal of …, 2021 - mdpi.com
Epigenetics involves a series of mechanisms that entail histone and DNA covalent
modifications and non-coding RNAs, and that collectively contribute to programing cell …