Over the last two decades, it has become evident that estrogens preserve the integrity of
energy homeostasis at central and peripheral levels. Estrogen deficiency, such as that …

In the last thirty years, obesity has reached epidemic proportions and is now regarded as a
major health issue in contemporary society trending to serious economic and social …

Until menopause, women have a lower propensity to develop metabolic diseases than men,
suggestive of a protective role for sex hormones. Although a functional synergy between …

Here, we demonstrate that hypothalamic astrocytic BMAL1 computes cyclic metabolic
information to optimize energetic resources in a sexually dimorphic manner. Knockdown of …

Alterations in metabolism, sleep patterns, body composition and hormone status are all key
features of aging. While the hypothalamus is a well-conserved brain region that controls …

The impact of sex and menopausal status in Alzheimer's disease remains understudied
despite increasing evidence of greater female risk, particularly in APOE4 carriers. Utilizing …

Obesity has become a global epidemic, and it is a major risk factor for other metabolic
disorders such as type 2 diabetes and cardiometabolic disease. Accumulating evidence …

Depression is a common psychological and mental disorder, characterized by low mood,
slow thinking and low will, and even suicidal tendencies in severe cases. It imposes a huge …

α-Estradiol (17aE2) treatment from 4 months of age extends life span in male mice and can
reduce neuroinflammatory responses in the hypothalamus of 12-month-old males. Although …

Women are subject to constitutional changes after menopause, which increases conditions
and diseases prone to cardiovascular risks such as obesity and diabetes mellitus. Both …