Sifting through the surfeit of neuroinflammation tracers
The first phase of molecular brain imaging of microglial activation in neuroinflammatory
conditions began some 20 years ago with the introduction of [11C]-(R)-PK11195, the …
conditions began some 20 years ago with the introduction of [11C]-(R)-PK11195, the …
Imaging microglial activation during neuroinflammation and Alzheimer's disease
S Venneti, CA Wiley, J Kofler - Journal of Neuroimmune Pharmacology, 2009 - Springer
Microglial activation is an important pathogenic component of neurodegenerative disease
processes. This state of increased inflammation is associated not only with neurotoxic …
processes. This state of increased inflammation is associated not only with neurotoxic …
PET imaging of the peripheral benzodiazepine receptor: monitoring disease progression and therapy response in neurodegenerative disorders
J Doorduin, EFJ de Vries, RA Dierckx… - Current …, 2008 - ingentaconnect.com
It is important to gain more insight into neurodegenerative diseases, because these
debilitating diseases can not be cured. A common characteristic of many neurological …
debilitating diseases can not be cured. A common characteristic of many neurological …
Normalization in PET group comparison studies—the importance of a valid reference region
P Borghammer, KY Jonsdottir, P Cumming… - Neuroimage, 2008 - Elsevier
INTRODUCTION: In positron emission tomography (PET) studies of cerebral blood flow
(CBF) and metabolism, the large interindividual variation commonly is minimized by …
(CBF) and metabolism, the large interindividual variation commonly is minimized by …
Low cerebral oxygen consumption and blood flow in patients with cirrhosis and an acute episode of hepatic encephalopathy
P Iversen, M Sørensen, LK Bak, HS Waagepetersen… - Gastroenterology, 2009 - Elsevier
BACKGROUND & AIMS: It is unclear whether patients with hepatic encephalopathy (HE)
have disturbed brain oxygen metabolism and blood flow. METHODS: We measured cerebral …
have disturbed brain oxygen metabolism and blood flow. METHODS: We measured cerebral …
Neurotransmitter receptor alterations in hepatic encephalopathy: a review
N Palomero-Gallagher, K Zilles - Archives of biochemistry and biophysics, 2013 - Elsevier
Hepatic encephalopathy (HE), a complex neuropsychiatric syndrome with symptoms
ranging from subtle neuropsychiatric and motor disturbances to deep coma and death, is …
ranging from subtle neuropsychiatric and motor disturbances to deep coma and death, is …
Artefactual subcortical hyperperfusion in PET studies normalized to global mean: lessons from Parkinson's disease
AIM: Recent studies of Parkinson's disease (PD) report subcortical increases of cerebral
blood flow (CBF) or cerebral metabolic rate of glucose (CMRglc), after conventional …
blood flow (CBF) or cerebral metabolic rate of glucose (CMRglc), after conventional …
PET tracers for the peripheral benzodiazepine receptor and uses thereof
The peripheral benzodiazepine receptor (PBR) is expressed on the outer mitochondrial
membrane of activated microglia and is implicated in the pathophysiology of a variety of …
membrane of activated microglia and is implicated in the pathophysiology of a variety of …
TSPO PET imaging: from microglial activation to peripheral sterile inflammatory diseases?
B Largeau, AC Dupont, D Guilloteau… - Contrast media & …, 2017 - Wiley Online Library
Peripheral sterile inflammatory diseases (PSIDs) are a heterogeneous group of disorders
that gathers several chronic insults involving the cardiovascular, respiratory, gastrointestinal …
that gathers several chronic insults involving the cardiovascular, respiratory, gastrointestinal …
Have (R)-[11C]PK11195 challengers fulfilled the promise? A scoping review of clinical TSPO PET studies
Purpose The prototypical TSPO radiotracer (R)-[11C] PK11195 has been used in humans
for more than thirty years to visualize neuroinflammation in several pathologies. Alternative …
for more than thirty years to visualize neuroinflammation in several pathologies. Alternative …