Sifting through the surfeit of neuroinflammation tracers

P Cumming, B Burgher, O Patkar… - Journal of Cerebral …, 2018 - journals.sagepub.com
The first phase of molecular brain imaging of microglial activation in neuroinflammatory
conditions began some 20 years ago with the introduction of [11C]-(R)-PK11195, the …

Imaging microglial activation during neuroinflammation and Alzheimer's disease

S Venneti, CA Wiley, J Kofler - Journal of Neuroimmune Pharmacology, 2009 - Springer
Microglial activation is an important pathogenic component of neurodegenerative disease
processes. This state of increased inflammation is associated not only with neurotoxic …

PET imaging of the peripheral benzodiazepine receptor: monitoring disease progression and therapy response in neurodegenerative disorders

J Doorduin, EFJ de Vries, RA Dierckx… - Current …, 2008 - ingentaconnect.com
It is important to gain more insight into neurodegenerative diseases, because these
debilitating diseases can not be cured. A common characteristic of many neurological …

Normalization in PET group comparison studies—the importance of a valid reference region

P Borghammer, KY Jonsdottir, P Cumming… - Neuroimage, 2008 - Elsevier
INTRODUCTION: In positron emission tomography (PET) studies of cerebral blood flow
(CBF) and metabolism, the large interindividual variation commonly is minimized by …

Low cerebral oxygen consumption and blood flow in patients with cirrhosis and an acute episode of hepatic encephalopathy

P Iversen, M Sørensen, LK Bak, HS Waagepetersen… - Gastroenterology, 2009 - Elsevier
BACKGROUND & AIMS: It is unclear whether patients with hepatic encephalopathy (HE)
have disturbed brain oxygen metabolism and blood flow. METHODS: We measured cerebral …

Neurotransmitter receptor alterations in hepatic encephalopathy: a review

N Palomero-Gallagher, K Zilles - Archives of biochemistry and biophysics, 2013 - Elsevier
Hepatic encephalopathy (HE), a complex neuropsychiatric syndrome with symptoms
ranging from subtle neuropsychiatric and motor disturbances to deep coma and death, is …

Artefactual subcortical hyperperfusion in PET studies normalized to global mean: lessons from Parkinson's disease

P Borghammer, P Cumming, J Aanerud, A Gjedde - Neuroimage, 2009 - Elsevier
AIM: Recent studies of Parkinson's disease (PD) report subcortical increases of cerebral
blood flow (CBF) or cerebral metabolic rate of glucose (CMRglc), after conventional …

PET tracers for the peripheral benzodiazepine receptor and uses thereof

PJ Schweitzer, BA Fallon, JJ Mann, JSD Kumar - Drug discovery today, 2010 - Elsevier
The peripheral benzodiazepine receptor (PBR) is expressed on the outer mitochondrial
membrane of activated microglia and is implicated in the pathophysiology of a variety of …

TSPO PET imaging: from microglial activation to peripheral sterile inflammatory diseases?

B Largeau, AC Dupont, D Guilloteau… - Contrast media & …, 2017 - Wiley Online Library
Peripheral sterile inflammatory diseases (PSIDs) are a heterogeneous group of disorders
that gathers several chronic insults involving the cardiovascular, respiratory, gastrointestinal …

Have (R)-[11C]PK11195 challengers fulfilled the promise? A scoping review of clinical TSPO PET studies

F Chauveau, G Becker, H Boutin - European journal of nuclear medicine …, 2021 - Springer
Purpose The prototypical TSPO radiotracer (R)-[11C] PK11195 has been used in humans
for more than thirty years to visualize neuroinflammation in several pathologies. Alternative …