HIV-1/AIDS remains a global public health problem. The world health organization (WHO)
reported at the end of 2019 that 38 million people were living with HIV-1 worldwide, of which …

The HIV latent reservoir represents the major challenge to cure development. Residing in
resting CD4+ T cells and myeloid cells at multiple locations in the body, including sanctuary …

Although HIV-1 replication can be efficiently suppressed to undetectable levels in peripheral
blood by combination antiretroviral therapy (cART), lifelong medication is still required in …

Defective HIV-1 proviruses represent a population of viral genomes that are selected for by
immune pressures, and clonally expanded to dominate the persistent HIV-1 proviral genome …

Latent HIV reservoir is the main obstacle that prevents a cure for HIV-1 (HIV). While
antiretroviral therapy is effective in controlling viral replication, it cannot eliminate latent HIV …

Antiretroviral therapy effectively controls human immunodeficiency virus (HIV) infection.
However, a reservoir of latently infected cells persists under suppressive therapy …

Oregano essential oil has long been known for its health-promoting benefits. Here, we report
its activity against viral replication. Oregano oil was found to specifically inhibit lentiviruses …

Current antiretroviral therapy (ART) increases the survival of HIV-infected individuals, yet it is
not curative. The major barrier to finding a definitive cure for HIV is our inability to identify …

Background Transcription from the integrated HIV-1 promoter is directly governed by its
chromatin environment, and the nucleosome-1 downstream from the transcription start site …

Human immunodeficiency virus type 1 (HIV-1) transactivator of transcription (Tat) is a potent
mediator involved in the development of HIV-1-associated neurocognitive disorders …