Recent advances in high-throughput technologies have enabled the profiling of multiple
layers of a biological system, including DNA sequence data (genomics), RNA expression …

Disturbances in cardiac metabolism underlie most cardiovascular diseases. Metabolomics,
one of the newer omics technologies, has emerged as a powerful tool for defining changes …

Metabolic processes can influence disease risk and provide therapeutic targets. By
conducting genome-wide association studies of 1,091 blood metabolites and 309 metabolite …

Host genetics are known to influence the gut microbiome, yet their role remains poorly
understood. To robustly characterize these effects, we performed a genome-wide …

Abstract Introduction: Background to metabolomics Metabolomics is the comprehensive
study of the metabolome, the repertoire of biochemicals (or small molecules) present in …

In cross-platform analyses of 174 metabolites, we identify 499 associations (P< 4.9× 10− 10)
characterized by pleiotropy, allelic heterogeneity, large and nonlinear effects and …

Genetic factors modifying the blood metabolome have been investigated through genome-
wide association studies (GWAS) of common genetic variants and through exome …

We integrated lipidomics and genomics to unravel the genetic architecture of lipid
metabolism and identify genetic variants associated with lipid species putatively in the …

Abstract Introduction The Alzheimer's Disease Research Summits of 2012 and 2015
incorporated experts from academia, industry, and nonprofit organizations to develop new …

The human plasma lipidome captures risk for cardiometabolic diseases. To discover new
lipid-associated variants and understand the link between lipid species and cardiometabolic …