Background Unraveling the mechanisms that regulate gene expression is a major challenge
in biology. An important task in this challenge is to identify regulatory elements, especially …

The identification of promoters and their regulatory elements is one of the major challenges
in bioinformatics and integrates comparative, structural, and functional genomics. Many …

PlantCARE is a database of plant cis-acting regulatory elements, enhancers and repressors.
Regulatory elements are represented by positional matrices, consensus sequences and …

A common question within the context of de novo motif discovery is whether a newly
discovered, putative motif resembles any previously discovered motif in an existing …

A versatile, platform independent and easy to use Java suite for large-scale gene
expression analysis was developed. Genesis integrates various tools for microarray data …

Genome-wide association studies have identified single nucleotide polymorphisms (SNPs)
in the 9p21 gene desert associated with coronary artery disease (CAD),,, and type 2 …

A single high dose of interferon‐β (IFNβ) activates powerful cellular responses, in which
many anti‐viral, pro‐apoptotic, and anti‐proliferative proteins are highly expressed. Since …

Background As nonmotile organisms, plants must rapidly adapt to ever-changing
environmental conditions, including those caused by daily light/dark cycles. One important …

Analyses of Arabidopsis thaliana defense response to the damping-off oomycete pathogen
Pythium irregulare show that resistance to P. irregulare requires a multicomponent defense …

The CBF cold response pathway has a prominent role in cold acclimation. The pathway
includes action of three transcription factors, CBF1, 2 and 3 (also known as DREB1b, c and …