In the mammalian heart, myocytes and fibroblasts can communicate via gap junction, or
connexin-mediated current flow. Some of the effects of this electrotonic coupling on the …

Cardiac side effects are one of the major causes of drug candidate failures in preclinical
drug development or in clinical trials and are responsible for the retraction of several already …

Complex heterocellular interactions between cardiomyocytes and fibroblasts in the heart
involve their bidirectional signaling via cell-cell contacts, paracrine factors, and extracellular …

Alignment of cardiomyocytes (CMCs) contributes to the anisotropic (direction-related) tissue
structure of the heart, thereby facilitating efficient electrical and mechanical activation of the …

Background HF incurs high disease burden, and the effectiveness of known HF treatments is
unsatisfactory. Therefore, seeking novel therapeutic target of HF is important. The present …

Introduction: The field of cardiac safety pharmacology has been experiencing exciting
changes over the recent years. Drug induced arrhythmia of the torsade des pointes types …

Mesenchymal stem cells (MSCs) were shown to improve cell survival and alleviate cardiac
arrhythmias when transplanted into cardiac tissue; however, little is known about the …

The myocardium of the developing heart tube is covered by epicardium. These epicardial
cells undergo a process of epithelial‐to‐mesenchymal transformation (EMT) and develop …

Aims Cardiac fibrosis is associated with increased incidence of cardiac arrhythmias, but the
underlying proarrhythmic mechanisms remain incompletely understood and antiarrhythmic …

In addition to mediating cell-to-cell electrical coupling, gap junctions are important in tissue
repair, wound healing, and scar formation. The expression and distribution of connexin43 …