PIK3CA vascular overgrowth syndromes: an update : Current Opinion in Pediatrics PIK3CA
vascular overgrowth syndromes: an update : Current Opinion in Pediatrics Log in or Register …

Overgrowth syndromes, diagnosis and management : Current Opinion in Pediatrics
Overgrowth syndromes, diagnosis and management : Current Opinion in Pediatrics Log in or …

Background Constitutional or somatic mosaic epimutations are increasingly recognized as a
mechanism of gene dysregulation resulting in cancer susceptibility. Beckwith‐Wiedemann …

Background Beckwith-Wiedemann Syndrome (BWS) is characterised by overgrowth and
tumour predisposition. While multiple epigenetic and genetic mechanisms cause BWS, the …

Background Megalencephaly-capillary malformation-polymicrogyria syndrome (MCAP)
belongs to a group of conditions called the PIK3CA-related overgrowth spectrum (PROS) …

Disorders of somatic mosaicism (DoSM) are a diverse group of syndromic and non-
syndromic conditions caused by mosaic variants in genes that regulate cell survival and …

Vascular malformations (VMs) are clinically diverse with regard to the vessel type,
anatomical location, tissue involvement and size. Consequently, symptoms and disease …

Mosaic RASopathies are a heterogeneous group of diseases characterized by the presence
at birth or early onset of congenital anomalies, cutaneous and vascular anomalies …

Background The genetic features and treatment strategies of lateralized overgrowth have
been elusive. We performed this study to analyze the genetic characteristics and treatment …

CLOVES syndrome is a novel sporadic mosaic segmental overgrowth syndrome, currently
categorized under the canopy of PROS (PIK3CA-related overgrowth spectrum) disorders. All …