Glycosylation: mechanisms, biological functions and clinical implications
M He, X Zhou, X Wang - Signal Transduction and Targeted Therapy, 2024 - nature.com
Protein post-translational modification (PTM) is a covalent process that occurs in proteins
during or after translation through the addition or removal of one or more functional groups …
during or after translation through the addition or removal of one or more functional groups …
Sialylation in the gut: From mucosal protection to disease pathogenesis
X Ma, M Li, X Wang, G Qi, L Wei, D Zhang - Carbohydrate Polymers, 2024 - Elsevier
Sialylation, a crucial post-translational modification of glycoconjugates, entails the
attachment of sialic acid (SA) to the terminal glycans of glycoproteins and glycolipids …
attachment of sialic acid (SA) to the terminal glycans of glycoproteins and glycolipids …
Fast Metabolic Glycan Labeling for Click-Labeling and Imaging of Sialoglycans in Living Acute Brain Slices from Mice and Human Patients
Living acute brain slices provide a practical platform for imaging sialylation in human brain
pathology. However, the limited lifespan of acute brain slices has impeded the use of …
pathology. However, the limited lifespan of acute brain slices has impeded the use of …
Analyzing and Modifying Sialic Acid at the Glycan End: Systematic Review of Methods and Functional Outcomes
Y We, L Zheng, Y Chen, J Jiao, J Jiao, Y Guo - TrAC Trends in Analytical …, 2024 - Elsevier
Sialic acid, a nine-carbon monosaccharide at the termini of glycan chains, is intricately
linked to tumor progression and disease, necessitating highly sensitive analytical methods …
linked to tumor progression and disease, necessitating highly sensitive analytical methods …
[HTML][HTML] MAPK/ERK signaling in gliomas modulates interferon responses, T cell recruitment, microglia phenotype, and immune checkpoint blockade efficacy
Background. Glioblastoma (GB) remains a formidable challenge in neuro-oncology, with
immune checkpoint blockade (ICB) showing limited efficacy in unselected patients. We …
immune checkpoint blockade (ICB) showing limited efficacy in unselected patients. We …
MAPK/ERK signaling in gliomas modulates interferon responses, T cell recruitment, enhances tumor-microglia crosstalk, and drives immune checkpoint blockade …
KS Kim, J Zhang, VA Arrieta, C Dmello, E Grabis… - bioRxiv, 2024 - biorxiv.org
Background: Glioblastoma (GB) remains a formidable challenge in neuro-oncology, with
immune checkpoint blockade (ICB) showing limited efficacy in unselected patients. We …
immune checkpoint blockade (ICB) showing limited efficacy in unselected patients. We …
Characterizing and targeting glioblastoma neuron-tumor networks with retrograde tracing
SK Tetzlaff, E Reyhan, N Layer, CP Bengtson, A Heuer… - Cell, 2024 - cell.com
Glioblastomas are invasive brain tumors with high therapeutic resistance. Neuron-to-glioma
synapses have been shown to promote glioblastoma progression. However, a …
synapses have been shown to promote glioblastoma progression. However, a …