Cells metabolize nutrients for biosynthetic and bioenergetic needs to fuel growth and
proliferation. The uptake of nutrients from the environment and their intracellular metabolism …

Novel targets to arrest neurodegeneration in several dementing conditions involving
misfolded protein accumulations may be found in the diverse signaling pathways of the …

The process of pyroptosis is mediated by inflammasomes and a downstream effector known
as gasdermin D (GSDMD). Upon cleavage by inflammasome-associated caspases, the N …

Cancer cells are frequently confronted with metabolic stress in tumor microenvironments
due to their rapid growth and limited nutrient supply. Metabolic stress induces cell death …

Background The brain was once thought of as an insulin-insensitive organ. We now know
that the insulin receptor is present throughout the brain and serves important functions in …

The mechanisms that link environmental and intracellular stimuli to mitochondrial functions,
including fission/fusion, ATP production, metabolite biogenesis, and apoptosis, are not well …

Cancer metabolism has long been equated with aerobic glycolysis, seen by early
biochemists as primitive and inefficient. Despite these early beliefs, the metabolic signatures …

Summary mRNA translation is thought to be the most energy-consuming process in the cell.
Translation and energy metabolism are dysregulated in a variety of diseases including …

Continuous proliferation of tumor cells requires constant adaptations of energy metabolism
to rapidly fuel cell growth and division. This energetic adaptation often comprises …

Reactive oxygen and nitrogen species change cellular responses through diverse
mechanisms that are now being defined. At low levels, they are signalling molecules, and at …