In primary Sjögren syndrome (pSS), the function of the salivary glands is often considerably
reduced. Multiple innate immune pathways are likely dysregulated in the salivary gland …

Salivary glands produce and secrete saliva, which is essential for maintaining oral health
and overall health. Understanding both the unique structure and physiological function of …

Sjögren's syndrome (SS) is an autoimmune disease characterized by the involvement of
exocrine glands such as the salivary and lacrimal glands. The minor salivary glands, from …

Sjögrens syndrome (SS) is caused by autoantibodies that attack proprioceptive salivary and
lacrimal gland tissues. Damage to the glands leads to dry mouth and eyes and affects …

Dry eye disease encompasses a broad range of etiologies and disease subtypes which
have similar clinical manifestations. Medications can cause dry eye disease or symptoms of …

Cancer immunotherapy, which seeks to stimulate a patient's own immune system to combat
cancer, is quickly becoming a central pillar of cancer therapeutics and has resulted in the …

In patients with primary Sjögren's syndrome (pSS), inflamed salivary gland (SG) tissue may
contain lymphoepithelial lesions (LELs). LELs are histopathological phenomena whereby B …

The advent of immune checkpoint inhibitor (ICI) therapy for treatment of cancers is
unfortunately coupled with a broad panoply of side effects, related to non-specific activation …

Introduction Almost one-quarter of immune checkpoint inhibitor (ICI) recipients experience
sicca syndrome, while Sjögren's disease (SjD) is estimated at 0.3-2.5%, possibly …

Immune Checkpoint Inhibitor-induced Sicca Syndrome - Rheumatic Disease Clinics Skip to
Main Content Advertisement Rheumatic Disease Clinics Log in Register Log in Subscribe Claim …