Urokinase plasminogen activator (uPA) is an extracellular matrix-degrading protease
involved in cancer invasion and metastasis, interacting with plasminogen activator inhibitor …

Introduction: The close relationship existing between aging and thrombosis has growingly
been studied in this last decade. The age‐related development of a prothrombotic …

Background and Objective: Despite striking advances in multimodality management, gastric
cancer (GC) remains the third cause of cancer mortality globally and identifying novel …

The urokinase plasminogen activator (uPA) system consists of the serine protease uPA, its
glycolipid-anchored receptor, uPAR and its 2 serpin inhibitors, plasminogen activator …

In 1878, Billroth discovered that tumor cells invest themselves in a fibrin thrombus, and he
hypothesized that fibrin promotes tumor growth and invasion. Since then, many observations …

We have tested the hypothesis that elevated concentrations of TNFα could impair
trophoblast invasion. Using first-trimester placental explant cultures, we have demonstrated …

Although obesity is a well-known risk factor for several cancers, its role on cancer survival is
poorly understood. We conducted a systematic literature review to assess the current …

Obesity is a complex disease caused by the interaction of a myriad of genetic, dietary,
lifestyle and environmental factors, which favors a chronic positive energy balance, leading …

Plasminogen activator inhibitor 1 (PAI-1) is the main inhibitor of tissue-type (t-PA) and
urokinase-type (u-PA) plasminogen activator and therefore plays an important role in the …

Increased expression of plasminogen activator inhibitor-1 (PAI-1) in cancer patients is
associated with unfavorable outcome, and the reason for this paradox has been poorly …