Despite tremendous successes in the field of antibiotic discovery seen in the previous
century, infectious diseases have remained a leading cause of death. More specifically …

Transient electric fields across cell bilayer membranes can lead to electroporation and cell
fusion, effects crucial to cell viability whose biological implications have been extensively …

Aggregation of amyloidogenic proteins is a characteristic of multiple neurodegenerative
diseases. Atomic resolution of small molecule binding to such pathological protein …

Oligomeric aggregates of the amyloid-beta peptide (1-42)(Aβ42) are regarded as a primary
cause of cytotoxicity related to membrane damage in Alzheimer's disease. However, a …

The routinely employed periodic boundary conditions complicate molecular simulations of
physiologically relevant asymmetric lipid membranes together with their distinct solvent …

Electric fields across lipid membranes play important roles in physiology, medicine, and
biotechnology, rationalizing the wide interest in modeling transmembrane potentials in …

It is desirable that nanopores that are components of biosensors are gated, ie, capable of
controllable switching between closed (impermeable) and open (permeable) states. A …

Ion channels play key roles in cell membranes, and recent advances are yielding an
increasing number of structures. However, their functional relevance is often unclear and …

Adsorption of metal cations onto a cellular membrane changes its properties, such as
interactions with charged moieties or the propensity for membrane fusion. It is, however …

Emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its
current worldwide spread have caused a pandemic of acute respiratory disease COVID-19 …