Apoptosis is crucial for the normal development of the nervous system, whereas neurons in
the adult CNS are relatively resistant to this form of cell death. However, under pathological …

Abstract Necrostatin-1 (Nec-1) is a RIP1-targeted inhibitor of necroptosis, a form of
programmed cell death discovered and investigated in recent years. There are already …

Neuroinflammation is a complex inflammatory process in the nervous system that is
expected to play a significant role in neurological diseases. Necroptosis is a kind of necrosis …

Neuroinflammation and necroptosis are major contributors to neurodegenerative disease,
and axon dysfunction and degeneration is often an initiating event. SARM1 is the central …

Glaucoma is a common neurodegenerative disease characterized by progressive retinal
ganglion cell (RGC) loss and visual field defects. Pathologically high intraocular pressure …

Acute ocular hypertension (AOH) is the most important characteristic of acute glaucoma,
which can lead to retinal ganglion cell (RGC) death and permanent vision loss. So far …

The discovery of the necroptosis, a form of regulated necrosis that is mediated by receptor-
interacting protein kinase 1 (RIPK1), RIPK3, and mixed-lineage kinase domain-like …

Pathways governing protein homeostasis are involved in maintaining the structural,
quantitative, and functional stability of intracellular proteins and involve the ubiquitin …

Necroptosis, an important form of programmed cell death (PCD), is a highly regulated
caspase-independent type of cell death that plays a critical role in the pathophysiology of …

The scaffolding function of receptor-interacting protein kinase 1 (RIPK1) regulates
prosurvival signaling and inflammatory gene expression, while its kinase activity mediates …