Mechanical stimuli have fundamental roles in articular cartilage during health and disease.
Chondrocytes respond to the physical properties of the cartilage extracellular matrix (ECM) …

The prevalence of osteoarthritis (OA) is rising for reasons that are not fully understood. In this
Opinion article, we review the possibility that OA is an evolutionary mismatch disease, which …

Osteoarthritis (OA) is a common degenerative joint disease characterized by cartilage
degradation, synovitis, subchondral bone sclerosis and osteophyte formation. Current …

Integrins are cell adhesion receptors that are evolutionary old and that play important roles
during developmental and pathological processes. The integrin family is composed of 24 αβ …

Articular cartilage injuries and degenerative joint diseases are responsible for progressive
pain and disability in millions of people worldwide, yet there is currently no treatment …

As the cellular component of articular cartilage, chondrocytes are responsible for
maintaining in a low-turnover state the unique composition and organization of the matrix …

Osteoarthritis (OA) represents a final and common pathway for all major traumatic insults to
synovial joints. OA is the most common form of degenerative joint disease and a major …

A wide range of cell types depend on mechanically induced signals to enable appropriate
physiological responses. The skeleton is particularly dependent on mechanical information …

The repair of articular cartilage defects remains a significant challenge in orthopedic
medicine. Hydrogels, three-dimensional polymer networks swollen in water, offer a unique …

Osteoarthritis (OA) is a prevalent disease of most mammalian species and is a significant
cause of welfare and economic morbidity in affected individuals and populations. In vitro …