The high selectivity and affinity of antibodies toward their antigens have made them a highly
valuable tool in disease therapy, diagnosis, and basic research. A plethora of chemical and …

The megamolecules with high ordered structures play an important role in chemical biology
and biomedical engineering. Self-assembly, a long-discovered but very appealing …

Electron microscopy of soft and biological materials, or “soft electron microscopy”, is
essential to the characterization of macromolecules. Soft microscopy is governed by …

This work describes the use of computational strategies to design megamolecule building
blocks for the self-assembly of lattice networks. The megamolecules are prepared by …

This paper describes the synthesis, characterization, and functional activity of 26
MegaMolecule-based bispecific antibody mimics for T-cell redirection toward HER2+ cancer …

This paper describes the synthesis, characterization, and modeling of a series of molecules
having four protein domains attached to a central core. The molecules were assembled with …

This paper presents an enzyme building block for the assembly of megamolecules. The
system is based on the inhibition of the human‐derived cellular retinoic acid binding protein …

In the last 30 years, recombinant antibodies have become an established tool for
interrogating basic research questions as well as supplementing clinical applications in both …

Cancer has long been the second-leading cause of death in the United States and
represents the leading cause of death in midlife (age 40–60). While the prognosis for many …

Advances in cryo-transmission electron microscopy (TEM), particularly hardware such as
direct electron detectors and software such as reconstruction algorithms and sparse …