Structural and biophysical mechanisms of class CG protein-coupled receptor function
A Ellaithy, J Gonzalez-Maeso, DA Logothetis… - Trends in biochemical …, 2020 - cell.com
Groundbreaking structural and spectroscopic studies of class AG protein-coupled receptors
(GPCRs), such as rhodopsin and the β 2 adrenergic receptor, have provided a picture of …
(GPCRs), such as rhodopsin and the β 2 adrenergic receptor, have provided a picture of …
[HTML][HTML] Membrane trafficking and positioning of mGluRs at presynaptic and postsynaptic sites of excitatory synapses
A Bodzęta, N Scheefhals, HD MacGillavry - Neuropharmacology, 2021 - Elsevier
The plethora of functions of glutamate in the brain are mediated by the complementary
actions of ionotropic and metabotropic glutamate receptors (mGluRs). The ionotropic …
actions of ionotropic and metabotropic glutamate receptors (mGluRs). The ionotropic …
Transcriptomic organization of the human brain in post-traumatic stress disorder
Despite extensive study of the neurobiological correlates of post-traumatic stress disorder
(PTSD), little is known about its molecular determinants. Here, differential gene expression …
(PTSD), little is known about its molecular determinants. Here, differential gene expression …
Homo-and hetero-dimeric subunit interactions set affinity and efficacy in metabotropic glutamate receptors
C Habrian, N Latorraca, Z Fu, EY Isacoff - Nature Communications, 2023 - nature.com
Metabotropic glutamate receptors (mGluRs) are dimeric class C G-protein–coupled
receptors that operate in glia and neurons. Glutamate affinity and efficacy vary greatly …
receptors that operate in glia and neurons. Glutamate affinity and efficacy vary greatly …
Presynaptic kainate receptors onto somatostatin interneurons are recruited by activity throughout development and contribute to cortical sensory adaptation
TJ Stachniak, AÖ Argunsah, JW Yang… - Journal of …, 2023 - Soc Neuroscience
Somatostatin (SST) interneurons produce delayed inhibition because of the short-term
facilitation of their excitatory inputs created by the expression of metabotropic glutamate …
facilitation of their excitatory inputs created by the expression of metabotropic glutamate …
Proper synaptic adhesion signaling in the control of neural circuit architecture and brain function
Trans-synaptic cell-adhesion molecules are critical for governing various stages of synapse
development and specifying neural circuit properties via the formation of multifarious …
development and specifying neural circuit properties via the formation of multifarious …
Beyond the ligand: extracellular and transcellular G protein–coupled receptor complexes in physiology and pharmacology
G protein–coupled receptors (GPCRs) remain one of the most successful targets of US Food
and Drug Administration–approved drugs. GPCR research has predominantly focused on …
and Drug Administration–approved drugs. GPCR research has predominantly focused on …
Regulation and dysregulation of neuronal circuits by KARs
C Mulle, V Crépel - Neuropharmacology, 2021 - Elsevier
Kainate receptors (KARs) constitute a family of ionotropic glutamate receptors (iGluRs) with
distinct physiological roles in synapses and neuronal circuits. Despite structural and …
distinct physiological roles in synapses and neuronal circuits. Despite structural and …
[HTML][HTML] A GRM7 mutation associated with developmental delay reduces mGlu7 expression and produces neurological phenotypes
NM Fisher, A AlHashim, AB Buch, H Badivuku… - JCI insight, 2021 - ncbi.nlm.nih.gov
The metabotropic glutamate receptor 7 (mGlu 7) is a G protein–coupled receptor that has
been recently linked to neurodevelopmental disorders. This association is supported by the …
been recently linked to neurodevelopmental disorders. This association is supported by the …
Targeting prefrontal cortex GABAergic microcircuits for the treatment of alcohol use disorder
Developing novel treatments for alcohol use disorders (AUDs) is of paramount importance
for improving patient outcomes and alleviating the suffering related to the disease. A better …
for improving patient outcomes and alleviating the suffering related to the disease. A better …