Hepatocellular carcinoma from epidemiology to prevention: translating knowledge into practice

AG Singal, HB El-Serag - Clinical gastroenterology and hepatology, 2015 - Elsevier
The epidemiology of hepatocellular carcinoma (HCC) is characterized by dynamic temporal
trends, several major established (ie, HCV, HBV, alcohol) and emerging (ie, diabetes …

[PDF][PDF] Epidemiology of hepatocellular carcinoma in the United States: where are we? Where do we go?

HB El‐Serag, F Kanwal - Hepatology, 2014 - Wiley Online Library
The incidence of hepatocellular carcinoma (HCC) has almost tripled since the early 1980s in
the United States, where it is the fastest rising cause of cancerrelated deaths. 1 According to …

[HTML][HTML] Risk of hepatocellular carcinoma in chronic hepatitis B: assessment and modification with current antiviral therapy

GV Papatheodoridis, HLY Chan, BE Hansen… - Journal of …, 2015 - Elsevier
In the treatment of chronic hepatitis B (CHB), the ultimate goal is preventing hepatitis B virus
(HBV)-associated liver disease, including hepatocellular carcinoma (HCC). Recently …

[PDF][PDF] Entecavir treatment reduces hepatic events and deaths in chronic hepatitis B patients with liver cirrhosis

GLH Wong, HLY Chan, CWH Mak, SKY Lee… - …, 2013 - Wiley Online Library
Entecavir is a potent antiviral agent with high genetic barrier to resistance, hence it is
currently recommended as first‐line antiviral therapy for chronic hepatitis B (CHB). The aim …

[PDF][PDF] Late HDV RNA relapse after peginterferon alpha‐based therapy of chronic hepatitis delta

B Heidrich, C Yurdaydın, G Kabacam, BA Ratsch… - …, 2014 - Wiley Online Library
Interferon alpha is the only treatment option for hepatitis delta virus (HDV). Trials
investigating the efficacy of pegylated interferon alpha (PEG‐IFNa) showed HDV RNA …

[HTML][HTML] Persistent low level of hepatitis B virus promotes fibrosis progression during therapy

Y Sun, X Wu, J Zhou, T Meng, B Wang, S Chen… - Clinical …, 2020 - Elsevier
Background & Aims Progression of liver fibrosis still occurs in some patients with chronic
hepatitis B virus (HBV) infection despite antiviral therapy. We aimed to identify risk factors for …

Four‐year entecavir therapy reduces hepatocellular carcinoma, cirrhotic events and mortality in chronic hepatitis B patients

TH Su, TH Hu, CY Chen, YH Huang… - Liver …, 2016 - Wiley Online Library
Abstract Background & Aims Oral antiviral therapy may reduce the disease progression of
chronic hepatitis B (CHB) patients. We aimed to further investigate the efficacy of long‐term …

Entecavir treatment does not eliminate the risk of hepatocellular carcinoma in chronic hepatitis B: limited role for risk scores in Caucasians

P Arends, MJ Sonneveld, R Zoutendijk, I Carey… - Gut, 2015 - gut.bmj.com
Background Hepatocellular carcinoma (HCC) risk-scores may predict HCC in Asian
entecavir (ETV)-treated patients. We aimed to study risk factors and performance of risk …

Epidemiology of hepatocellular carcinoma

HB El‐Serag - The liver: Biology and pathobiology, 2020 - Wiley Online Library
Liver cancer, of which hepatocellular carcinoma (HCC) is the dominant variety, represents
the fourth leading cause of cancer deaths worldwide. The geographic map of the incidence …

Serum alanine aminotransferase flares in chronic hepatitis B infection: the good and the bad

MG Ghany, JJ Feld, KM Chang, HLY Chan… - The lancet …, 2020 - thelancet.com
Chronic hepatitis B virus (HBV) infection follows a dynamic and variable course. At different
stages in the disease, hepatitis flares might occur, which can be challenging to predict and …