P450c17 commands a central role in human steroidogenesis as the qualitative regulator of
steroid hormone flux (Fig. 1). Analysis of P450c17 deficiencies in humans illustrates many …

Congenital adrenal hyperplasia (CAH) comprises a group of autosomal recessive disorders,
which are usually due to inactivating mutations in single enzymes involved in adrenal …

Abstract The cytochrome P450 (P450) enzymes first attracted interest because of their
relevance to the metabolism of drugs, steroids, and carcinogens. Collectively, the 57 human …

Much of P450 research has always been done with the view of appUcation to humans, even
when done with experimental animals and microorganisms. Research with the human …

We performed molecular genetic analysis of 24 subjects from 19 families with 17-
hydroxylase deficiency in Brazil. Of 7 novel CYP17 mutations, 2 (W406R and R362C) …

Abstract P450c17 (17α-hydroxylase/17, 20-lyase) catalyzes steroid 17α-hydroxylase and 17,
20-lyase activities in the biosynthesis of androgens and estrogens. These two activities are …

Cytochrome P450c17 catalyzes steroid 17α-hydroxylase and 17, 20-lyase activities and
hence is a key enzyme in the production of human glucocorticoids and sex steroids. These …

Cytochrome P450s play critical roles in the metabolism of various bioactive compounds.
One of the crucial functions of cytochrome P450s in Chordata is in the biosynthesis of steroid …

Context: Disorders of steroidogenesis have been instrumental in delineating human
steroidogenic pathways. Each genetic disorder seemed to correspond to a different …

The microsomal enzyme cytochrome P450c17 is an important regulator of steroidogenesis.
The enzyme has two functions: 17α-hydroxylase and 17, 20-lyase activities. These functions …