Sirtuins (SIRTs) are nicotine adenine dinucleotide (+)-dependent histone deacetylases
regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in …

Abstract Sirtuin 3 (SIRT3) is one of the most prominent deacetylases that can regulate
acetylation levels in mitochondria, which are essential for eukaryotic life and inextricably …

To promote new thinking of the pathogenesis of Alzheimer's disease (AD), we examine the
central role of mitochondrial dysfunction in AD. Pathologically, AD is characterized by …

Alzheimer disease (AD) is a major cause of age-related dementia. We do not fully
understand AD aetiology and pathogenesis, but oxidative damage is a key component. The …

Alzheimer's disease (AD) is a neurodegenerative disorder accounting for over 50% of all
dementia patients and representing a leading cause of death worldwide for the global …

Aging has been linked to several degenerative processes that, through the accumulation of
molecular and cellular damage, can progressively lead to cell dysfunction and organ failure …

L-lactate was long considered a glycolytic by-product but is now being recognized as a
signaling molecule involved in cell survival. In this manuscript, we report the role of L-lactate …

Abstract Background Hydrogen peroxide (H 2 O 2)-induced mitochondrial oxidative damage
is critical to intestinal ischemia/reperfusion (I/R) injury, and PRDX3 is an efficient H 2 O 2 …

The brain is particularly susceptible to oxidative damage which is a key feature of several
neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD) …

It has been illustrated that metabolic syndrome (MetS) is associated with Alzheimer disease
(AD) neuropathology. Components of MetS including central obesity, hypertension, insulin …