Immune aging, dysmetabolism, and inflammation in neurological diseases
M Deleidi, M Jäggle, G Rubino - Frontiers in neuroscience, 2015 - frontiersin.org
As we age, the immune system undergoes a process of senescence accompanied by the
increased production of proinflammatory cytokines, a chronic subclinical condition named as …
increased production of proinflammatory cytokines, a chronic subclinical condition named as …
The complement system in schizophrenia: where are we now and what's next?
The complement system is a set of immune proteins involved in first-line defense against
pathogens and removal of waste materials. Recent evidence has implicated the complement …
pathogens and removal of waste materials. Recent evidence has implicated the complement …
Biological insights from 108 schizophrenia-associated genetic loci
C Pantelis, GN Papadimitriou, S Papiol… - Nature, 2014 - nature.com
Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of
alleles, including common alleles of small effect that might be detected by genome-wide …
alleles, including common alleles of small effect that might be detected by genome-wide …
[HTML][HTML] Biological insights from 108 schizophrenia-associated genetic loci
Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of
alleles, including common alleles of small effect that might be detected by genome-wide …
alleles, including common alleles of small effect that might be detected by genome-wide …
Genome-wide association analysis identifies 13 new risk loci for schizophrenia
S Ripke, C O'dushlaine, K Chambert, JL Moran… - Nature …, 2013 - nature.com
Schizophrenia is an idiopathic mental disorder with a heritable component and a substantial
public health impact. We conducted a multi-stage genome-wide association study (GWAS) …
public health impact. We conducted a multi-stage genome-wide association study (GWAS) …
De novo mutations in schizophrenia implicate chromatin remodeling and support a genetic overlap with autism and intellectual disability
Schizophrenia is a serious psychiatric disorder with a broadly undiscovered genetic
etiology. Recent studies of de novo mutations (DNMs) in schizophrenia and autism have …
etiology. Recent studies of de novo mutations (DNMs) in schizophrenia and autism have …
Anti-inflammatory effects of 2nd generation antipsychotics in patients with schizophrenia: A systematic review and meta-analysis
Background Schizophrenia is a major psychiatric disorder with unknown aetiology. Recent
evidence suggests a potential role for cytokines in its pathophysiology and that antipsychotic …
evidence suggests a potential role for cytokines in its pathophysiology and that antipsychotic …
Evidence for a dysregulated immune system in the etiology of psychiatric disorders
SM Gibney, HA Drexhage - Journal of Neuroimmune Pharmacology, 2013 - Springer
There is extensive bi-directional communication between the brain and the immune system
in both health and disease. In recent years, the role of an altered immune system in the …
in both health and disease. In recent years, the role of an altered immune system in the …
Genome-wide significant associations in schizophrenia to ITIH3/4, CACNA1C and SDCCAG8, and extensive replication of associations reported by the Schizophrenia …
ML Hamshere, JTR Walters, R Smith, AL Richards… - Molecular …, 2013 - nature.com
Abstract The Schizophrenia Psychiatric Genome-Wide Association Study Consortium (PGC)
highlighted 81 single-nucleotide polymorphisms (SNPs) with moderate evidence for …
highlighted 81 single-nucleotide polymorphisms (SNPs) with moderate evidence for …
Genetic associations between voltage-gated calcium channels and psychiatric disorders
Psychiatric disorders are mental, behavioral or emotional disorders. These conditions are
prevalent, one in four adults suffer from any type of psychiatric disorders world-wide. It has …
prevalent, one in four adults suffer from any type of psychiatric disorders world-wide. It has …