Nonalcoholic steatohepatitis-related hepatocellular carcinoma: pathogenesis and treatment

JM Llovet, CE Willoughby, AG Singal… - Nature reviews …, 2023 - nature.com
Nonalcoholic fatty liver disease (NAFLD), including its more severe manifestation,
nonalcoholic steatohepatitis (NASH), has a global prevalence of 20–25% and is a major …

[HTML][HTML] Lipid alterations in chronic liver disease and liver cancer

B Paul, M Lewinska, JB Andersen - JHEP reports, 2022 - Elsevier
Lipids are a complex and diverse group of molecules with crucial roles in many
physiological processes, as well as in the onset, progression, and maintenance of cancers …

Targeting immune cells in the tumor microenvironment of HCC: new opportunities and challenges

X Hao, G Sun, Y Zhang, X Kong, D Rong… - Frontiers in cell and …, 2021 - frontiersin.org
Immune associated cells in the microenvironment have a significant impact on the
development and progression of hepatocellular carcinoma (HCC) and have received more …

Therapeutic targets, novel drugs, and delivery systems for diabetes associated NAFLD and liver fibrosis

V Kumar, X Xin, J Ma, C Tan, N Osna… - Advanced drug delivery …, 2021 - Elsevier
Type 2 diabetes mellitus (T2DM) associated non-alcoholic fatty liver disease (NAFLD) is the
fourth-leading cause of death. Hyperglycemia induces various complications, including …

An immune-related gene signature for predicting survival and immunotherapy efficacy in hepatocellular carcinoma

Y Dai, W Qiang, K Lin, Y Gui, X Lan, D Wang - Cancer Immunology …, 2021 - Springer
Background Hepatocellular carcinoma (HCC) ranks the fourth in terms of cancer-related
mortality globally. Herein, in this research, we attempted to develop a novel immune-related …

PPAR-α modulators as current and potential cancer treatments

Y Tan, M Wang, K Yang, T Chi, Z Liao, P Wei - Frontiers in oncology, 2021 - frontiersin.org
Cancer is one of the leading causes of mortality worldwide. PPAR modulators may hold
great potential for the management of cancer patients. Indeed, PPARs are critical sensors …

Progression on the roles and mechanisms of tumor-infiltrating T lymphocytes in patients with hepatocellular carcinoma

X Zheng, W Jin, S Wang, H Ding - Frontiers in immunology, 2021 - frontiersin.org
Primary liver cancer (PLC) is one of the most common malignancies in China, where it ranks
second in mortality and fifth in morbidity. Currently, liver transplantation, hepatic tumor …

[HTML][HTML] Inhibition of carnitine palmitoyltransferase 1A in hepatic stellate cells protects against fibrosis

MF Fondevila, U Fernandez, V Heras, T Parracho… - Journal of …, 2022 - Elsevier
Background & Aims The pathogenesis of liver fibrosis requires activation of hepatic stellate
cells (HSCs); once activated, HSCs lose intracellular fatty acids but the role of fatty acid …

Multicenter validation of association between decline in MRI‐PDFF and histologic response in NASH

R Loomba, BA Neuschwander‐Tetri, A Sanyal… - Hepatology, 2020 - journals.lww.com
Bespoken Nanoceria: An Effective Treatment in Experimental H... : Hepatology Bespoken
Nanoceria: An Effective Treatment in Experimental Hepatocellular Carcinoma : Hepatology …

Adjuvant treatment of hepatocellular carcinoma: prospect of immunotherapy

ZJ Brown, TF Greten, B Heinrich - Hepatology, 2019 - journals.lww.com
Cell‐fate determination is influenced by interactions between master transcription factors
(TFs) and cis‐regulatory elements. Hepatocyte nuclear factor 4 alpha (HNF4A), a liver …