Control of HIV-1 gene expression depends on two viral regulatory proteins, Tat and Rev. Tat
stimulates transcription elongation by directing the cellular transcriptional elongation factor P …

▪ Abstract Alternative pre-mRNA splicing is a central mode of genetic regulation in higher
eukaryotes. Variability in splicing patterns is a major source of protein diversity from the …

▪ Abstract The nuclear export of intron-containing HIV-1 RNA is critically dependent on the
activity of Rev, a virally encoded sequence-specific RNA-binding protein. Rev shuttles …

Although the viral genome is often quite small, it encodes a broad series of proteins. The
virus takes advantage of the host-RNA-processing machinery to provide the alternative …

Splice site consensus sequences alone are insufficient to dictate the recognition of real
constitutive splice sites within the typically large transcripts of higher eukaryotes, and large …

Splicing of the human immunodeficiency virus type 1 (HIV‐1) pre‐mRNA must be inefficient
to provide a pool of unspliced messages which encode viral proteins and serve as genomes …

Over 40 different human immunodeficiency virus type 1 (HIV-1) mRNA species, both
completely and incompletely spliced, are produced by alternative splicing of the primary viral …

Tissue-and stage-specific alternative splicing events are widespread in mammals, yet the
factors and mechanisms that direct these important posttranscriptional events are poorly …

Defective HIV-1 proviruses represent a population of viral genomes that are selected for by
immune pressures, and clonally expanded to dominate the persistent HIV-1 proviral genome …

In vitro selection strategies have typically been used to identify a preferred ligand, usually an
RNA, for an identified protein. Ideally, one would like to know RNA consensus sequences …