The identification of the human cannabinoid receptors and their roles in health and disease,
has been one of the most significant biochemical and pharmacological advancements to …

The recent identification of cannabinoid receptors and their endogenous lipid ligands has
triggered an exponential growth of studies exploring the endocannabinoid system and its …

Publisher Summary This chapter describes the role of γ‐aminobutyric acid (GABA) in the
mediation and perception of pain. The anatomical distribution of GABA neurons and …

Although the presence of functional GABAB receptors in mammalian brain has been known
for more than 20 years, there is still only one therapeutic agent in use, baclofen, which …

Glutamate and γ-amino butyric acid (GABA) are respectively two major excitatory and
inhibitory neurotransmitters of the adult mammalian central nervous system. These …

Pain is the most common sensation installed in us naturally which plays a vital role in
defending us against severe harm. This neurological mechanism pathway has been one of …

Derivatives of the plant Cannabis sativa have been used for centuries for both medical and
recreational purposes, as well as industrial. The first proof of its medicinal use comes from …

Recent physiological, pharmacological and anatomical studies provide evidence that one of
the main roles of the endocannabinoid system in the brain is the regulation of γ …

Decades of research have been devoted to defining the role of GABAergic transmission in
nociceptive processing. Much of this work was performed using rigid, orthosteric GABA …

Understanding how the body regulates pain is fundamental to develop rational strategies to
combat the growing prevalence of chronic pain states, opioid dependency, and the …