In order to meet the high energy demand, a metabolic reprogramming occurs in cancer cells.
Its role is crucial in promoting tumor survival. Among the substrates in demand, oxygen is …

Oxygen deprivation or hypoxia characterizes a number of serious pathological conditions
and elicits a number of adaptive changes that are mainly mediated at the transcriptional …

Abstract Hypoxia inducible factor (HIF)-1 and HIF-2 are heterodimeric transcription factors
mediating the cellular response to hypoxia. Recent data indicate that not only ubiquitous HIF …

Adaptation to hypoxia involves hypoxia-inducible transcription factors (HIFs) and requires
reprogramming of cellular metabolism that is essential during both physiological and …

The final step in the cell cycle is the formation of two genetically identical daughter cells by
cytokinesis. At the heart of cytokinesis in animal cells is the centralspindlin complex which is …

Abstract Hypoxia inducible factor-1 (HIF-1) is the main transcriptional activator of the cellular
response to hypoxia and an important target of anticancer therapy. Phosphorylation by …

Hypoxia-inducible factor 1 (HIF-1) is the key transcriptional activator of hypoxia-inducible
genes and an important anti-cancer target. Its regulated subunit, HIF-1α, is controlled by …

Abstract Hypoxia inducible factor-1 (HIF-1) supports survival of normal cells under low
oxygen concentration and cancer cells in the hypoxic tumor microenvironment. This involves …

Hypoxia is frequently encountered in the microenvironment of solid tumors. Hypoxia-
inducible factors (HIFs), the main effectors of cell response to hypoxia, promote cancer cell …

Cancer cells, when exposed to the hypoxic tumour microenvironment, respond by activating
hypoxia‐inducible factors (HIFs). HIF‐1 mediates extensive metabolic re‐programming, and …