Opioid receptors in immune and glial cells—implications for pain control
H Machelska, MÖ Celik - Frontiers in immunology, 2020 - frontiersin.org
Opioid receptors comprise μ (MOP), δ (DOP), κ (KOP), and nociceptin/orphanin FQ (NOP)
receptors. Opioids are agonists of MOP, DOP, and KOP receptors, whereas …
receptors. Opioids are agonists of MOP, DOP, and KOP receptors, whereas …
[HTML][HTML] The role of the M1/M2 microglia in the process from cancer pain to morphine tolerance
H Tu, H Chu, S Guan, F Hao, N Xu, Z Zhao, Y Liang - Tissue and Cell, 2021 - Elsevier
Cancer pain, especially bone cancer pain, is a pain state often caused by inflammation or
dysfunctional nerves. Moreover, in the management of cancer pain, opioid especially …
dysfunctional nerves. Moreover, in the management of cancer pain, opioid especially …
A deep convolutional neural network for efficient microglia detection
I Suleymanova, D Bychkov, J Kopra - Scientific Reports, 2023 - nature.com
Microglial cells are a type of glial cells that make up 10–15% of all brain cells, and they play
a significant role in neurodegenerative disorders and cardiovascular diseases. Despite their …
a significant role in neurodegenerative disorders and cardiovascular diseases. Despite their …
Microglial TLR4-induced TAK1 phosphorylation and NLRP3 activation mediates neuroinflammation and contributes to chronic morphine-induced antinociceptive …
H Wang, M Huang, W Wang, Y Zhang, X Ma… - Pharmacological …, 2021 - Elsevier
Background and purpose The aim of this work was to investigate the role and signal
transduction of toll-like receptor 4 (TLR4), TGF-β-activated kinase 1 (TAK1) and nod-like …
transduction of toll-like receptor 4 (TLR4), TGF-β-activated kinase 1 (TAK1) and nod-like …
Microglia express mu opioid receptor: insights from transcriptomics and fluorescent reporter mice
Background: Microglia activation contributes to chronic pain and to the adverse effects of
opiate use such as analgesic tolerance and opioid-induced hyperalgesia. Both mu opioid …
opiate use such as analgesic tolerance and opioid-induced hyperalgesia. Both mu opioid …
Mu opioid receptor in microglia contributes to morphine analgesic tolerance, hyperalgesia, and withdrawal in mice
D Reiss, T Maduna, H Maurin… - Journal of …, 2022 - Wiley Online Library
A major challenge in medicine is developing potent pain therapies without the adverse
effects of opiates. Neuroinflammation and in particular microglial activation have been …
effects of opiates. Neuroinflammation and in particular microglial activation have been …
Glial IL-33 signaling through an ST2-to-CXCL12 pathway in the spinal cord contributes to morphine-induced hyperalgesia and tolerance
XM Hu, W Yang, MT Zhang, LX Du, JH Tian, JY Zhu… - Science …, 2021 - science.org
Morphine and other opiates are highly effective for treating moderate to severe pain.
However, morphine-induced hyperalgesia and analgesic tolerance prevent durable efficacy …
However, morphine-induced hyperalgesia and analgesic tolerance prevent durable efficacy …
Morphine promotes microglial activation by upregulating the EGFR/ERK signaling pathway
Y Yang, Y Sun, R Hu, J Yan, Z Wang, W Li, H Jiang - PLoS One, 2021 - journals.plos.org
Although they represent the cornerstone of analgesic therapy, opioids, such as morphine,
are limited in efficacy by drug tolerance, hyperalgesia and other side effects. Activation of …
are limited in efficacy by drug tolerance, hyperalgesia and other side effects. Activation of …
Spared nerve injury causes sexually dimorphic mechanical allodynia and differential gene expression in spinal cords and dorsal root ganglia in rats
FHG Ahlström, K Mätlik, H Viisanen, KJ Blomqvist… - Molecular …, 2021 - Springer
Neuropathic pain is more prevalent in women. However, females are under-represented in
animal experiments, and the mechanisms of sex differences remain inadequately …
animal experiments, and the mechanisms of sex differences remain inadequately …
A deep convolutional neural network approach for astrocyte detection
Astrocytes are involved in various brain pathologies including trauma, stroke,
neurodegenerative disorders such as Alzheimer's and Parkinson's diseases, or chronic …
neurodegenerative disorders such as Alzheimer's and Parkinson's diseases, or chronic …