Omics-based investigations of breast cancer

AN Neagu, D Whitham, P Bruno, H Morrissiey… - Molecules, 2023 - mdpi.com
Breast cancer (BC) is characterized by an extensive genotypic and phenotypic
heterogeneity. In-depth investigations into the molecular bases of BC phenotypes …

[HTML][HTML] Outcomes in breast cancer—does ethnicity matter?

YS Yap - ESMO open, 2023 - Elsevier
Ethnic or racial differences in breast cancer (BC) survival outcomes have been reported, but
current data are largely restricted to comparisons between African Americans and non …

Epigenetic biomarkers for disease susceptibility and preventative medicine

MK Skinner - Cell metabolism, 2024 - cell.com
The development of molecular biomarkers for disease makes it possible for preventative
medicine approaches to be considered. Therefore, therapeutics, treatments, or clinical …

Gender-Specific Genetic Predisposition to Breast Cancer: BRCA Genes and Beyond

V Valentini, A Bucalo, G Conti, L Celli, V Porzio… - Cancers, 2024 - mdpi.com
Simple Summary The role of gender in oncology is an issue that is starting to be recognized
as being of extreme importance in the last few years. While breast cancer is commonly …

[HTML][HTML] Роль высокопенетрантных мутаций в генах BRCA1 и CHEK2 в характере ассоциаций полиморфизма генов матриксных металлопротеиназ с раком …

НВ Павлова, ВС Орлова, ИВ Батлуцкая… - Научные …, 2022 - cyberleninka.ru
Актуальность: Рак молочной железы (РМЖ) это опухоль молочной железы
злокачественного характера, которая занимает ведущее место как в структуре …

DNA damage repair-related genes signature for immune infiltration and outcome in cervical cancer

X Wang, C Xu, H Sun - Frontiers in Genetics, 2022 - frontiersin.org
Background: The mechanism of DNA damage repair plays an important role in many solid
tumors represented by cervical cancer. Purpose: The purpose of this study was to explore …

Development and testing of a polygenic risk score for breast cancer aggressiveness

Y Shieh, J Roger, C Yau, DM Wolf, GL Hirst… - NPJ precision …, 2023 - nature.com
Aggressive breast cancers portend a poor prognosis, but current polygenic risk scores
(PRSs) for breast cancer do not reliably predict aggressive cancers. Aggressiveness can be …

Cis-and trans-eQTL TWASs of breast and ovarian cancer identify more than 100 susceptibility genes in the BCAC and OCAC consortia

ST Head, F Dezem, A Todor, J Yang, J Plummer… - The American Journal of …, 2024 - cell.com
Transcriptome-wide association studies (TWASs) have investigated the role of genetically
regulated transcriptional activity in the etiologies of breast and ovarian cancer. However …

Germline pathogenic variants associated with triple-negative breast cancer in US Hispanic and Guatemalan women using hospital and community-based recruitment …

JM Godinez Paredes, I Rodriguez, M Ren… - Breast Cancer Research …, 2024 - Springer
Purpose Recruit and sequence breast cancer subjects in Guatemalan and US Hispanic
populations. Identify optimum strategies to recruit Latin American and Hispanic women into …

Reassessing the causal role of early-life adiposity in breast cancer: could the apparent inverse associations be a manifestation of survival bias?

CM Schooling, K Fei, MB Terry - International Journal of …, 2023 - academic.oup.com
Hao et al. 1 present an extensive examination of the role of adiposity in female breast cancer
(BC) using comprehensive Mendelian randomization (MR) methods. Previous MR studies of …