LNCing RNA to immunity
DC Peltier, A Roberts, P Reddy - Trends in immunology, 2022 - cell.com
Despite an ever-increasing appreciation of how protein-coding genes shape immune
responses, the molecular underpinnings of immune regulation remain incompletely …
responses, the molecular underpinnings of immune regulation remain incompletely …
Haploinsufficient Transcription Factors in Myeloid Neoplasms
TC Martinez, ME McNerney - Annual Review of Pathology …, 2024 - annualreviews.org
Many transcription factors (TFs) function as tumor suppressor genes with heterozygous
phenotypes, yet haploinsufficiency generally has an underappreciated role in neoplasia …
phenotypes, yet haploinsufficiency generally has an underappreciated role in neoplasia …
The effects of cannabidiol via TRPV2 channel in chronic myeloid leukemia cells and its combination with imatinib
F Maggi, MB Morelli, D Tomassoni, O Marinelli… - Cancer …, 2022 - Wiley Online Library
Chronic myeloid leukemia (CML) is a myeloproliferative disorder characterized by
accumulation of immature cells in bone marrow and peripheral blood. Although successful …
accumulation of immature cells in bone marrow and peripheral blood. Although successful …
Core-binding factor fusion downregulation of ADAR2 RNA editing contributes to AML leukemogenesis
Adenosine-to-inosine RNA editing, which is catalyzed by adenosine deaminases acting on
RNA (ADAR) family of enzymes, ADAR1 and ADAR2, has been shown to contribute to …
RNA (ADAR) family of enzymes, ADAR1 and ADAR2, has been shown to contribute to …
CRISPRi screens identify the lncRNA, LOUP, as a multifunctional locus regulating macrophage differentiation and inflammatory signaling
H Halasz, E Malekos, S Covarrubias… - Proceedings of the …, 2024 - National Acad Sciences
Long noncoding RNAs (lncRNAs) account for the largest portion of RNA from the
transcriptome, yet most of their functions remain unknown. Here, we performed two …
transcriptome, yet most of their functions remain unknown. Here, we performed two …
RNA demethylase ALKBH5 promotes tumorigenesis of t (8; 21) acute myeloid leukemia via ITPA m6A modification
R Li, X Wu, K Xue, D Feng, J Li, J Li - Biomarker Research, 2023 - Springer
Abstract Background Although t (8; 21) is in fact considered a good risk acute myeloid
leukemia (AML), only 60% of the patients live beyond 5 years after diagnosis. Studies have …
leukemia (AML), only 60% of the patients live beyond 5 years after diagnosis. Studies have …
RUNX1 interacts with lncRNA SMANTIS to regulate monocytic cell functions
Monocytes, the circulating macrophage precursors, contribute to diseases like
atherosclerosis and asthma. Long non-coding RNAs (lncRNAs) have been shown to …
atherosclerosis and asthma. Long non-coding RNAs (lncRNAs) have been shown to …
The tip of the iceberg—The roles of long noncoding RNAs in acute myeloid leukemia
P Connerty, RB Lock - Wiley Interdisciplinary Reviews: RNA, 2023 - Wiley Online Library
Long noncoding RNAs (lncRNAs) are traditionally defined as RNA transcripts longer than
200 nucleotides that have no protein coding potential. LncRNAs have been identified to be …
200 nucleotides that have no protein coding potential. LncRNAs have been identified to be …
Chromatin structure and 3D architecture define the differential functions of PU.1 regulatory elements in blood cell lineages
K Qiu, DC Vu, L Wang, NN Nguyen… - Epigenetics & …, 2024 - Springer
The precise spatiotemporal expression of the hematopoietic ETS transcription factor PU. 1, a
key determinant of hematopoietic cell fates, is tightly regulated at the chromatin level …
key determinant of hematopoietic cell fates, is tightly regulated at the chromatin level …
Diverse functions of long noncoding RNAs in acute myeloid leukemia: Emerging roles in pathophysiology, prognosis, and treatment resistance
Diverse functions of long noncoding RNAs in acute myeloid le... : Current Opinion in
Hematology Diverse functions of long noncoding RNAs in acute myeloid leukemia: emerging …
Hematology Diverse functions of long noncoding RNAs in acute myeloid leukemia: emerging …