Membrane-initiated estrogen, androgen, and progesterone receptor signaling in health and disease
Rapid effects of steroid hormones were discovered in the early 1950s, but the subject was
dominated in the 1970s by discoveries of estradiol and progesterone stimulating protein …
dominated in the 1970s by discoveries of estradiol and progesterone stimulating protein …
Progesterone receptors, their isoforms and progesterone regulated transcription
BM Jacobsen, KB Horwitz - Molecular and cellular endocrinology, 2012 - Elsevier
This review discusses mechanisms by which progesterone receptors (PR) regulate
transcription. We examine available data in different species and tissues regarding:(1) …
transcription. We examine available data in different species and tissues regarding:(1) …
Progesterone synthesis in the nervous system: implications for myelination and myelin repair
M Schumacher, R Hussain, N Gago… - Frontiers in …, 2012 - frontiersin.org
Progesterone is well known as a female reproductive hormone and in particular for its role in
uterine receptivity, implantation, and the maintenance of pregnancy. However …
uterine receptivity, implantation, and the maintenance of pregnancy. However …
Progesterone action in breast, uterine, and ovarian cancers
Progesterone and progesterone receptors (PRs) are essential for the development and
cyclical regulation of hormone-responsive tissues including the breast and reproductive …
cyclical regulation of hormone-responsive tissues including the breast and reproductive …
The biology of progesterone receptor in the normal mammary gland and in breast cancer
AE Obr, DP Edwards - Molecular and cellular endocrinology, 2012 - Elsevier
This paper reviews work on progesterone and the progesterone receptor (PR) in the mouse
mammary gland that has been used extensively as an experimental model. Studies have led …
mammary gland that has been used extensively as an experimental model. Studies have led …
Progesterone receptor action: defining a role in breast cancer
AR Daniel, CR Hagan, CA Lange - Expert review of endocrinology …, 2011 - Taylor & Francis
The ovarian steroid hormones, estradiol and progesterone, and their nuclear receptors
(estrogen receptor [ER] and progesterone receptor [PR]), are involved in breast cancer …
(estrogen receptor [ER] and progesterone receptor [PR]), are involved in breast cancer …
Progesterone receptor-B enhances estrogen responsiveness of breast cancer cells via scaffolding PELP1-and estrogen receptor-containing transcription complexes
AR Daniel, AL Gaviglio, TP Knutson, JH Ostrander… - Oncogene, 2015 - nature.com
Progesterone and estrogen are important drivers of breast cancer proliferation. Herein, we
probed estrogen receptor-α (ER) and progesterone receptor (PR) cross-talk in breast cancer …
probed estrogen receptor-α (ER) and progesterone receptor (PR) cross-talk in breast cancer …
Modulation of innate immune response to viruses including SARS-CoV-2 by progesterone
S Su, D Hua, JP Li, XN Zhang, L Bai, LB Cao… - … and Targeted Therapy, 2022 - nature.com
Whether and how innate antiviral response is regulated by humoral metabolism remains
enigmatic. We show that viral infection induces progesterone via the hypothalamic-pituitary …
enigmatic. We show that viral infection induces progesterone via the hypothalamic-pituitary …
Progesterone modulates neuronal excitability bidirectionally
J Kapur, S Joshi - Neuroscience letters, 2021 - Elsevier
Progesterone acts on neurons directly by activating its receptor and through metabolic
conversion to neurosteroids. There is emerging evidence that progesterone exerts excitatory …
conversion to neurosteroids. There is emerging evidence that progesterone exerts excitatory …
Phosphorylated and sumoylation-deficient progesterone receptors drive proliferative gene signatures during breast cancer progression
TP Knutson, AR Daniel, D Fan, KAT Silverstein… - Breast cancer …, 2012 - Springer
Introduction Progesterone receptors (PR) are emerging as important breast cancer drivers.
Phosphorylation events common to breast cancer cells impact PR transcriptional activity, in …
Phosphorylation events common to breast cancer cells impact PR transcriptional activity, in …