Membrane-initiated estrogen, androgen, and progesterone receptor signaling in health and disease

F Mauvais-Jarvis, CA Lange, ER Levin - Endocrine reviews, 2022 - academic.oup.com
Rapid effects of steroid hormones were discovered in the early 1950s, but the subject was
dominated in the 1970s by discoveries of estradiol and progesterone stimulating protein …

Progesterone receptors, their isoforms and progesterone regulated transcription

BM Jacobsen, KB Horwitz - Molecular and cellular endocrinology, 2012 - Elsevier
This review discusses mechanisms by which progesterone receptors (PR) regulate
transcription. We examine available data in different species and tissues regarding:(1) …

Progesterone synthesis in the nervous system: implications for myelination and myelin repair

M Schumacher, R Hussain, N Gago… - Frontiers in …, 2012 - frontiersin.org
Progesterone is well known as a female reproductive hormone and in particular for its role in
uterine receptivity, implantation, and the maintenance of pregnancy. However …

Progesterone action in breast, uterine, and ovarian cancers

CH Diep, AR Daniel, LJ Mauro… - Journal of …, 2015 - jme.bioscientifica.com
Progesterone and progesterone receptors (PRs) are essential for the development and
cyclical regulation of hormone-responsive tissues including the breast and reproductive …

The biology of progesterone receptor in the normal mammary gland and in breast cancer

AE Obr, DP Edwards - Molecular and cellular endocrinology, 2012 - Elsevier
This paper reviews work on progesterone and the progesterone receptor (PR) in the mouse
mammary gland that has been used extensively as an experimental model. Studies have led …

Progesterone receptor action: defining a role in breast cancer

AR Daniel, CR Hagan, CA Lange - Expert review of endocrinology …, 2011 - Taylor & Francis
The ovarian steroid hormones, estradiol and progesterone, and their nuclear receptors
(estrogen receptor [ER] and progesterone receptor [PR]), are involved in breast cancer …

Progesterone receptor-B enhances estrogen responsiveness of breast cancer cells via scaffolding PELP1-and estrogen receptor-containing transcription complexes

AR Daniel, AL Gaviglio, TP Knutson, JH Ostrander… - Oncogene, 2015 - nature.com
Progesterone and estrogen are important drivers of breast cancer proliferation. Herein, we
probed estrogen receptor-α (ER) and progesterone receptor (PR) cross-talk in breast cancer …

Modulation of innate immune response to viruses including SARS-CoV-2 by progesterone

S Su, D Hua, JP Li, XN Zhang, L Bai, LB Cao… - … and Targeted Therapy, 2022 - nature.com
Whether and how innate antiviral response is regulated by humoral metabolism remains
enigmatic. We show that viral infection induces progesterone via the hypothalamic-pituitary …

Progesterone modulates neuronal excitability bidirectionally

J Kapur, S Joshi - Neuroscience letters, 2021 - Elsevier
Progesterone acts on neurons directly by activating its receptor and through metabolic
conversion to neurosteroids. There is emerging evidence that progesterone exerts excitatory …

Phosphorylated and sumoylation-deficient progesterone receptors drive proliferative gene signatures during breast cancer progression

TP Knutson, AR Daniel, D Fan, KAT Silverstein… - Breast cancer …, 2012 - Springer
Introduction Progesterone receptors (PR) are emerging as important breast cancer drivers.
Phosphorylation events common to breast cancer cells impact PR transcriptional activity, in …