Naturally acquired immunity to falciparum malaria protects millions of people routinely
exposed to Plasmodium falciparum infection from severe disease and death. There is no …

Malaria, a mosquito‐borne infectious disease caused by parasites of the genus Plasmodium
continues to be a major health problem worldwide. The unicellular Plasmodium‐parasites …

Background During the past decade, renewed global and national efforts to combat malaria
have led to ambitious goals. We aimed to provide an accurate assessment of the levels and …

There are still approximately 500 million cases of malaria and 1 million deaths from malaria
each year. Yet recently, malaria incidence has been dramatically reduced in some parts of …

Greater than 80% of malaria-related mortality occurs in sub-Saharan Africa due to infections
with Plasmodium falciparum. The majority of P. falciparum-related mortality occurs in …

Clinical manifestations of Plasmodium falciparum infection are induced by the asexual
stages of the parasite that develop inside red blood cells (RBCs). Because splenic …

Iron deficiency anemia and child mortality are public health problems requiring urgent
attention. However, the degree to which iron deficiency anemia contributes to child mortality …

Background The phase 3 trial of the RTS, S/AS01 malaria vaccine candidate showed
modest efficacy of the vaccine against Plasmodium falciparum malaria, but was not powered …

Cerebral malaria is the most severe neurological complication of Plasmodium falciparum
malaria. Even though this type of malaria is most common in children living in sub-Saharan …

Many human genetic associations with resistance to malaria have been reported, but few
have been reliably replicated. We collected data on 11,890 cases of severe malaria due to …