Inflammation, a process intimately linked to renal disease, can be defined as a complex
network of interactions between renal parenchymal cells and resident immune cells, such as …

All progressive renal diseases are the consequence of a process of destructive fibrosis. This
review will focus on tubulointerstitial fibrosis, the pathophysiology of which will be divided …

AKI is increasingly recognized as a major risk factor for progression to CKD. However, the
factors governing AKI to CKD progression are poorly understood. In this study, we …

ACE2, initially cloned from a human heart, is a recently described homologue of angiotensin-
converting enzyme (ACE) but contains only a single enzymatic site that catalyzes the …

Diabetic nephropathy seems to occur as a result of an interaction of metabolic and
haemodynamic factors. Glucose dependent pathways are activated within the diabetic …

The renin-angiotensin system (RAS) has been recognized for many years as critical
pathway for blood pressure control and kidney functions. Although most of the well-known …

Chronic kidney disease (CKD) comprises a group of pathologies in which the renal
excretory function is chronically compromised. Most, but not all, forms of CKD are …

It is estimated that over 10% of the adult population in developed countries have some
degree of chronic kidney disease (CKD). CKD is a progressive and irreversible deterioration …

The renal renin–angiotensin system plays a major role in determining the rate of chronic
renal disease progression. Treatment with activators of the vitamin D receptor retards the …

Collectrin, a novel homolog of angiotensin-converting enzyme-related carboxypeptidase
(ACE2), was identified during polymerase chain reaction-based cDNA subtraction and up …