Simple Summary The protein methyltransferase SETD7 is essential for epigenetic regulation
through methylation of histone H3 and non-histone proteins, including cell cycle, apoptosis …

Reactive oxygen species (ROS) induce multiple signaling cascades in the cell and hence
play an important role in the regulation of the cell's fate. ROS can cause irreversible damage …

Histone modification regulates replication-coupled nucleosome assembly, DNA damage
repair, and gene transcription. Changes or mutations in factors involved in nucleosome …

Lysine-specific methyltransferase 7 (KMT7) SET7/9, aka Set7, Set9, or SetD7, or KMT5 was
discovered 20 years ago, yet its biological role remains rather enigmatic. In this review, we …

Breast cancer has gradually become the predominant cause for cancer-associated death in
women. The metastatic dissemination and underlying mechanisms of triple-negative breast …

Autophagy is a highly conserved process of cellular self-digestion that involves the formation
of autophagosomes for the delivery of intracellular components and dysfunctional …

Background Non-small cell lung cancer (NSCLC) accounts for 81% of lung cancer cases,
among which over 47% presented with distant metastasis at the time of diagnosis. Despite …

The contributions of aberrantly expressed metabolic enzymes to gastric cancer (GC)
initiation and progression have been widely appreciated in recent years. Acetyl-CoA …

SETD7 (SET7/9, KMT7) is a lysine methyltransferase that targets master regulators of cell
proliferation and differentiation. Here, the impact of inhibiting SETD7 catalytic activity on …

The protein-specific methyltransferase Set7/9 is known for its ability to add methyl groups to
lysine residues on many targets, including as histones H1. 4, H2A, H2B, H3, and non …